期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 14, 期 14, 页码 3510-3520出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ob00139d
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资金
- state administration of traditional Chinese medicine on the industry of Chinese medicine scientific research special project [201307002]
Twelve new diterpenes, caryopincaolide A-L (1-4, 11-12, 16-19, 27-28), together with twenty-eight known diterpenes, have been isolated from the whole plant of Caryopteris incana (Thunb.) Miq. Their structures were elucidated on the basis of 1D and 2D NMR, IR, X-ray crystal diffraction and mass spectroscopic data, as well as ECD calculations. All compounds were tested for in vitro dipeptidyl peptidase IV (DPP-IV) inhibitory activity, with compounds 3, 4, 28, 29, and 40 exhibiting DPP-IV inhibitory effects with IC50 values ranging from 54.2 to 228.9 mu M. Compounds 1, 3 and 4 also showed potent activity toward the inhibition of the growth of human cancer cells and 1 can induce apoptosis in Hey and A-549 cells.
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