期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 14, 期 2, 页码 598-611出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ob02040a
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资金
- RSF [14-23-00199]
Sulfated polysaccharides, fucoidans, from brown algae are built up mainly of alpha-L-fucopyranosyl units and form a group of natural biopolymers with a wide spectrum of biological activities. Systematic synthesis of oligosaccharides representing fucoidans' fragments gives molecular probes for detecting pharmacophores within fucoidan polysaccharide chains. Recently, it was discovered that the fucoidan from brown seaweed Chordaria flagelliformis contains not only alpha-L-fucopyranosyl units but also alpha-L-fucofuranosyl ones. To establish the influence of the unusual alpha-L-fucofuranose residue on the biological activity and conformational properties of fucoidans, the synthesis of selectively O-sulfated pentasaccharides, which represent the main repeating unit of the fucoidan from C. flagelliformis, was performed. The features of the synthesis were the use of the pyranoside-into-furanoside rearrangement to prepare the fucofuranoside precursor and remote stereocontrolling participation of O-acyl groups to manage stereoselective alpha-bond formation in glycosylation reactions.
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