期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 14, 期 34, 页码 8064-8067出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ob01382a
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资金
- CHEMO
- Royal Society
Three complementary biocatalytic routes were examined for the synthesis of the cyclopropyl amine (1R,2S)-2, which is a key building block for the anti-thrombotic agent ticagrelor 1. By employing either a ketoreductase, amidase or lipase biocatalyst, the key building blocks for synthesis of the amine 2 were obtained in 99.9, 92.5 and 46.3 ee, respectively.
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