期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 14, 期 39, 页码 9348-9353出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ob01550f
关键词
-
资金
- National Natural Science Foundation of China [21462017, 21662013]
- Hunan Provincial Natural Science Foundation of China [2015JJ2113]
- Hunan Provincial Education Department [16A171]
- Research Innovation Program for Graduates of Jishou University [JGY201636]
A simple and efficient copper-controlled divergent cyclization of benzamides, which leads to perfluorinated or cyanated isoquinolinediones, is developed. In the presence of AIBN, methacryloyl benzamides with perfluoroalkyl iodides undergo cascade radical addition/cyclization to afford perfluoroinated isoquinolinediones as the major product under metal-free conditions, whereas the use of CuI (10 mol%) is able to redirect the cyclization to yield isoquinolinediones bearing an alpha-cyano quaternary carbon center. The cyclization features controllable divergent synthesis and a broad substrate scope as well as highly practical reaction conditions, thereby making this strategy a highly attractive means to fluorinate or cyanate isoquinolinediones.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据