期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 14, 期 37, 页码 8743-8757出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ob01189f
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资金
- Federal funds from the Division of Microbiology and Infectious Diseases, National Institute of Allergy and infectious Diseases, National Institutes of Health, Department of Health and Human Services [HHSN272201100013I]
In an attempt to identify novel nucleoside phosphoramidate analogues for improving the anti-HCV activity of 2'-C-Me-uridine, we have synthesized for the first time a series of L-glutamic acid, L-serine, L-threonine and L-tyrosine containing aryloxyphosphoramidate prodrugs of 2'-C-Me-uridine. Evaluation of their activity against HCV revealed that they displayed very potent anti-HCV activity, with EC50 values that are in the same range as of Sofosbuvir.
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