Efficient generation of perfluoroalkyl radicals from sodium perfluoroalkanesulfinates and a hypervalent iodine(III) reagent: mild, metal-free synthesis of perfluoroalkylated organic molecules

This article describes an efficient method for the introduction of perfluoroalkyl groups into N-acrylamides, 2-isocyanides, olefins, and other heterocycles using perfluoroalkyl radicals that were generated from the reaction between sodium perfluoroalkanesulfinates and a hypervalent iodine(III) reagent. This approach represents a simple, scalable perfluoroalkylation method under mild and metal-free conditions.