4.6 Article

Palladium-catalyzed paraformaldehyde insertion: a three-component synthesis of benzofurans

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ORGANIC & BIOMOLECULAR CHEMISTRY
卷 14, 期 10, 页码 2819-2823

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ob00198j

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资金

  1. National Natural Science Foundation of China [21372187, 21572194]
  2. Program for Innovative Research Cultivation Team in the University of the Ministry of Education of China [1337304]
  3. Hunan Provincial Innovative Foundation [CX2014B264]

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An efficient procedure for 2-aroylbenzofuran preparation from 2-bromophenols, phenacyl bromides and paraformaldehyde is described. The cheap and stable paraformaldehyde served as the carbon source via an in situ formylation reaction.

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