期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 14, 期 48, 页码 11454-11461出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ob02158a
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资金
- Guru Gobind Singh Indraprastha University, New Delhi
- UGC
A series of thiourea based bifunctional organocatalysts having D-glucose as a core scaffold were synthesized and examined as catalysts for the asymmetric Michael addition reaction of aryl/alkyl trans-beta-nitrostyrenes over cyclohexanone and other Michael donors having active methylene. Excellent enantioselectivities (<95%), diastereoselectivities (<99%), and yields (<99%) were attained under solvent free conditions using 10 mol% of 1d(0). The obtained results were explained through DFT calculations using the B3LYP/6-311G(d, p)//B3LYP/6-31G(d) basic set. The QM/MM calculations revealed the role of cyclohexanone as a solvent as well as reactant in the rate determining step imparting 31.91 kcal mol(-1) of energy towards the product formation.
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