期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 14, 期 48, 页码 11488-11501出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ob02135b
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资金
- BBSRC at Bath [BB/D0127831, BB/J009164/1, BB0113291, BB/J009318/1]
- BBSRC at UCL
- University of Bath Faculty of Science
- Biotechnology and Biological Sciences Research Council [BB/J009318/1, BB/J009164/1] Funding Source: researchfish
- BBSRC [BB/J009318/1, BB/J009164/1] Funding Source: UKRI
Efficient syntheses of cell-penetrating peptide-porphyrin conjugates are described using a variety of bio-conjugation chemistries. This provides a flexible means to convert essentially hydrophobic tetrapyrolle photosensitisers into amphiphilic derivatives which are well-suited for use in light-triggered drug delivery by photochemical internalisation (PCI) and targeted photodynamic therapy (PDT).
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