4.6 Article

Palladium-catalyzed direct arylation of indoles with arylsulfonyl hydrazides

期刊

ORGANIC & BIOMOLECULAR CHEMISTRY
卷 14, 期 10, 页码 2824-2827

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ob02569a

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资金

  1. National Natural Science Foundation of China [21202154]
  2. Natural Science Foundation of Jiangsu Higher Education Institutes of China [15KJB150007]
  3. Nanjing Institute of Technology Scientific Research Foundation [YKJ201329, YKJ201326, YKJ201318, YKJ201419]
  4. Nanjing Institute of Technology

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A novel method to synthesise 2-arylindoles is demonstrated via direct arylation of indoles with arylsulfonyl hydrazides. Under the optimized reaction conditions, the reaction well tolerates a wide variety of functional groups to afford structurally diverse 2-arylindoles in good to excellent yields at 70 degrees C.

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