期刊
ORAL DISEASES
卷 23, 期 2, 页码 168-180出版社
WILEY
DOI: 10.1111/odi.12468
关键词
Toll-like receptors; periodontopathic bacteria; TLRs-mediated pathways; periodontitis
资金
- Science and Technology Foundation of the Health and Family Planning Commission of Guizhou province, China [gzwjkj2015-1-026]
- National Natural Science Foundation of China [81550011]
- Natural Science Foundation of Guangdong Province of China [2015A030313299]
- Scientific research projects of Guangzhou Medical University [2015C43]
- Medical Research Foundation of Guangdong Province [A2015132]
Periodontitis is a common infectious disease. Recent studies have indicated that the progression of periodontitis may be regulated by interactions between host immunity and periodontopathic bacteria. Although periodontopathic bacteria can destroy periodontal tissue, a dysfunctional host immune response triggered by the bacteria can lead to more severe and persistent destruction. Toll-like receptors (TLRs), a type of pattern recognition receptor (PRR) that recognizes pathogens, have been implicated in host innate immune responses to periodontopathic bacteria and in the activation of adaptive immunity. TLR-targeted drugs may hold promise to treat periodontal disease. This review summarizes recent studies on the role of TLRs in periodontitis and discusses areas needing further research. We believe TLRs may be an effective biomarker for the prevention, diagnosis, and treatment of periodontitis in the near future.
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