期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 21, 期 47, 页码 16823-16827出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201503647
关键词
carbonates; cross-coupling; decarboxylative coupling; palladium; stereospecificity
资金
- JSPS KAKENHI [15K13696, 15H05485, 24225002]
- Grants-in-Aid for Scientific Research [15K13696, 25620084, 15H05485] Funding Source: KAKEN
A palladium-catalyzed intermolecular decarboxylative C(sp(3))-C(sp) coupling of diarylmethyl carbonates and terminal alkynes has been developed. The reaction proceeds smoothly under external base-free conditions to deliver the corresponding alkynylated diarylmethanes with the liberation of CO2 and MeOH as the sole byproducts. Moreover, enantioenriched diarylmethyl carbonates are stereospecifically converted to optically active cross-coupling products with inversion of configuration. Thus, the stereospecific palladium catalysis can provide new and unique access to the alkynylated chiral tertiary stereocenters, which are relatively difficult to construct by conventional methods.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据