期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 21, 期 28, 页码 10131-10137出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201500290
关键词
CH bond activation; cleavage reactions; density function calculations; quinolines; rhodium
资金
- National Science Foundation of China [21372266, 51302327, 21272231, 21472186]
- Foundation of 100 Young Chongqing University [0903005203191]
Metal-catalyzed CH activation not only offers important strategies to construct new bonds, it also allows the merge of important research areas. When quinoline N-oxide is used as an arene source in CH activation studies, the NO bond can act as a directing group as well as an O-atom donor. The newly reported density functional theory method, M11L, has been used to elucidate the mechanistic details of the coupling between quinoline NO bond and alkynes, which results in CH activation and O-atom transfer. The computational results indicated that the most favorable pathway involves an electrophilic deprotonation, an insertion of an acetylene group into a RhC bond, a reductive elimination to form an oxazinoquinolinium-coordinated Rh-I intermediate, an oxidative addition to break the NO bond, and a protonation reaction to regenerate the active catalyst. The regioselectivity of the reaction has also been studied by using prop-1-yn-1-ylbenzene as a model unsymmetrical substrate. Theoretical calculations suggested that 1-phenyl-2-quinolinylpropanone would be the major product because of better conjugation between the phenyl group and enolate moiety in the corresponding transition state of the regioselectivity-determining step. These calculated data are consistent with the experimental observations.
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