期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 21, 期 19, 页码 7057-7060出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201500569
关键词
cascade reactions; cyclization; enynes; heterocycles; palladium
资金
- National Natural Science Foundation of P. R. China [21372202]
- New Century Excellent Talents in University program [NCET-12-1086]
- Zhejiang Natural Science Fund for Distinguished Young Scholars [R14B020005]
A palladium-catalyzed three-component cascade reaction of 2-(2-enynyl)pyridines with nucleophiles and allyl halides has been developed, enabling the synthesis of densely functionalized indolizines in moderate to good yields. The newly developed methodology offers several practical advantages, including operational simplicity, ready availability of starting materials, and mild reaction conditions.
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