期刊
OPTICS LETTERS
卷 41, 期 8, 页码 1720-1723出版社
OPTICAL SOC AMER
DOI: 10.1364/OL.41.001720
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- Stichting voor de Technische Wetenschappen (STW) (vici-grant) [10831]
In photoacoustic spectroscopy (PAS), wavelength dependent optical attenuation of biological tissue presents a challenge to measure the absolute oxygen saturation of hemoglobin (sO(2)). Here, we employ the combination of photoacoustics and acousto-optics (AO) at two optical wavelengths to achieve quantification, where AO serves as a sensor for the relative local fluence. We demonstrate that our method enables compensation of spatial as well as wavelength dependent fluence variations in PAS without a priori knowledge about the optical properties of the medium. The fluence compensated photoacoustic images at two excitation wavelengths are used to estimate the absolute oxygen saturation of blood in a spatially and spectroscopically heterogeneous phantom. (C) 2016 Optical Society of America
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