期刊
OPTICS EXPRESS
卷 24, 期 11, 页码 2166-2191出版社
Optica Publishing Group
DOI: 10.1364/OE.24.012166
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资金
- Natural Sciences and Engineering Research Council of Canada
- National Natural Science Foundation of China [11374378]
- start-up funding of Soochow University
A conceptual lab-in-a-photonic-crystal biosensor is demonstrated that can multiplex four or more distinct disease-markers and distinguish their presence and combinations simultaneously with unique spectral fingerprints. This biosensor consists of a photonic-band-gap, multi-mode waveguide coupled to surface modes on either side, encased in a glass slide with microfluidic channels. The spectral fingerprints consist of multiple peaks in optical transmission vs. frequency that respond sensitively and uniquely in both frequency shift and nonmonotonic change of peak transmittance levels to various analyte bindings. This special property enables complete, logical determination of twelve different combinations of four distinct disease-markers through one scan of the transmission spectrum. The results reveal unique phenomena such as switching between the strong-coupling and weak-coupling combinations of surface states by analyte binding at different locations along the central waveguide. The unconventional transmission spectra are explained using a Landauer-Buttiker, multiple-scattering, transmission theory that reproduces the main features of the exact finite-difference-time-domain simulation. (C) 2016 Optical Society of America
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