期刊
OPTICS EXPRESS
卷 24, 期 25, 页码 28247-28255出版社
OPTICAL SOC AMER
DOI: 10.1364/OE.24.028247
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资金
- National Natural Science Foundation of China [21671108]
- National Program for Support of Top-Notch Young Professionals, Scientific and Technological Innovation Teams of Colleges and Universities in Jiangsu Province [TJ215006]
- Natural Science Foundation of Jiangsu Province of China [BK20130038, BK20141422, BK20160885]
- Priority Academic Program Development of Jiangsu Higher Education Institutions [YX03001]
A novel phosphorescent probe based on ion-paired iridium(III) complex has been designed and synthesized by incorporating alpha,beta-unsaturated ketone moiety in the cationic component. The phosphorescent intensity of cationic component is sensitive to bithiols, such as cysteine and homocysteine, based on the addition reaction of bithiols with alpha,beta-unsaturated ketone moiety, while that of the anionic component remains unchanged. Thus, this ion-paired iridium(III) complex can be used for ratiometric luminescence sensing and imaging of intracellular biothiols with excellent sensing performance. Moreover, the long phosphorescence lifetime of the cationic component is also sensitive to bithiols. Hence, this ion-paired iridium(III) complex has been further used for time-resolved luminescence imaging of intracellular biothiols. As far as we know, this is the first report about molecular probe for both ratiometric and time-resolved luminescence imaging of intracellular biothiols. (C) 2016 Optical Society of America
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