期刊
ONCOLOGY RESEARCH
卷 24, 期 4, 页码 215-223出版社
COGNIZANT COMMUNICATION CORP
DOI: 10.3727/096504016X14634208143021
关键词
Acute myeloid leukemia (AML); HS-5 cells; Multidrug resistance; PI3K/Akt signaling pathway
类别
资金
- National Natural Science Foundation of China [81441004]
- Fujian Provincial National Fund [2014J01325]
- Fujian Provincial Innovation Fund [2014-CX-13]
- Fujian Medical University Professor Fund [JS14024]
- Personnel Training Program of Fujian Provincial Health System for Youth Backbone Talents [2014-ZQN-JC-10]
- National and Fujian Provincial Key Clinical Specialty Discipline Construction Program, P.R.C.
This study aimed to investigate the role of the PI3K/Akt signaling pathway in multidrug resistance of acute myeloid leukemia (AML) cells induced by cocultured stromal cells. Human AML cell lines HL-60 and U937 were adhesion cocultured with human bone marrow stromal cell line HS-5 cells. Such coculturing induced HL-60 and U937 cells resistant to chemotherapeutic drugs including daunorubicin (DNR), homoharringtonine (HHT), and cytosine arabinoside (Ara-C). The coculturing-induced resistance of AML cells to DNR, HHT, and Ara-C can be partially reversed by inhibition of the PI3K/Akt signaling pathway. Clinically, AML patients with a low level of PTEN and a high level of CCND1 had high relapse rates within 1 year, and newly diagnosed AML patients with extramedullary infiltration had a low level of PTEN. This study confirms the involvement of the PI3K/Akt signaling pathway in multidrug resistance in AML cells induced by stroma and suggests that the expression of PTEN and CCND1 may be a prognostic indicator for AML.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据