期刊
ONCOLOGY REPORTS
卷 36, 期 5, 页码 2553-2562出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2016.5129
关键词
miR-210; prognosis; angiogenesis; fibroblast growth factor receptor-like 1; hepatocellular carcinoma
类别
资金
- founding of National Key Basic Research Program of China [2014CB542102]
- National High Technology Research and Development Program of China [2013AA032202]
- Science Fund for Creative Research Groups, NSFC, China [81221061, 81372207]
- National Natural Science Foundation of China [81502416, 81572791]
- Innovation Program of Shanghai Municipal Education Commission [11ZZ76]
- Shanghai Municipal Commission of Health and Family Planning Project [140822111537488]
Hypoxia drives cancer to become more aggressive, particularly angiogenesis, and the corresponding mechanisms still need to be further investigated. In hepatocellular carcinoma (HCC), the master hypoxia-induced microRNA (miRNA) miR-210 is upregulated in HCC and participates in HCC progression, but its roles in hypoxia-induced HCC angiogenesis are still unknown. Moreover, the correlation between miR-210 expression and HCC clinical progression also needs elucidation. In the present study, we found that miR-210 expression was progressively increased from normal liver and adjacent non-tumor tissues, to incipient and advanced tumor tissues. In HCC patients, high miR-210 expression was significantly correlated with poor prognosis, both tumor-free survival and overall survival. Moreover, miR-210 expression in HCC was significantly positively correlated with microvascular density. Both in vitro and in vivo studies determined that miR-210 promoted HCC angiogenesis, and the corresponding mechanism was identified to be the direct targeting and inhibition of fibroblast growth factor receptor-like 1 (FGFRL1) expression. Thus, we suggest a new prognosis predictor for HCC patients, and determined the roles of hypoxic miR-210 in HCC angiogenesis.
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