期刊
ONCOLOGY REPORTS
卷 36, 期 2, 页码 803-810出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2016.4885
关键词
endometrial cancer; Frizzled2; epithelial-mesenchymal transition; metastasis; Wnt signaling
类别
资金
- National Natural Science Foundation of China [81172476, 81272885, 81472427]
- Science and Technology Commission of Shanghai Municipality [13JC1404501]
- Ministry of Education of China [20120073110090]
- Program for Young Excellent Talents in Tongji University [1400813]
The Wnt signaling pathway is essential for embryonic development, and genetic alteration in this network is closely correlated with tumorigenesis and progression. Previous research has shown that Wnt receptor Frizzled2 (Fzd2) is elevated in many metastatic cancer cell lines and high grade tumors. Yet, little is known about the Fzd2 expression and activity in human endometrial cancer (EC). In this study, we present evidence of a direct role of Fzd2 in human EC. We found that Fzd2 expression was higher in EC than that in adjacent normal tissues, and was correlated with epithelial-mesenchymal transition markers. Next, it was determined that the stable overexpression of Fzd2 in HEC-1B and Ishikawa cells promoted cell migration and induced an EMT phenotype. Conversely, RNA interference-mediated depletion of Fzd2 inhibited EC cell migration. Additionally, mechanistic investigation revealed that elevated Fzd2 expression activated canonical Wnt signaling and was blocked by canonical Wnt signaling inhibitor XAV939. However, Fzd2 did not influence the proliferation of EC cells. Thus, Fzd2 may be a potential marker for EC metastasis and a target for future therapies for this disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据