期刊
ONCOLOGY REPORTS
卷 35, 期 5, 页码 2665-2672出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2016.4623
关键词
cell proliferation; bladder cancer; cigarette smoke extract; NF-kappa B pathway
类别
资金
- National Natural Science Foundation of China [81373005, 81072330, 81202194]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Bladder cancer is a common genitourinary malignant disease worldwide. Convincing evidence shows that cigarette smoke (CS) is a crucial risk factor for bladder cancer, yet the role of the NF-kappa B signaling pathway in the development of CS-associated bladder cancer has not been fully elucidated. In the present study, we found that exposure to cigarette smoke extract (CSE) induced proliferation and triggered the transition of normal human urothelial cells from G1 to S phase. Moreover, CSE exposure enhanced the expression of cyclin D1and proliferating cell nuclear antigen (PCNA) and decreased the expression of p21 in SV-HUC-1 cells. Furthermore, the levels of nuclear NF-kappa B p65/p50 were significantly elevated by CSE. Pre-treatment with the NF-kappa B inhibitor (PDTC) reversed CSE-triggered cell proliferation. Taken together, our study revealed that CSE induced proliferation of normal human urothelial cells through the NF-kappa B pathway, and these data enhance our understanding of the CSE-related carcinogenesis of bladder cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据