期刊
ONCOGENE
卷 35, 期 35, 页码 4549-4557出版社
SPRINGERNATURE
DOI: 10.1038/onc.2016.9
关键词
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资金
- 973 Program of the Ministry of Science and Technology of China [2012CB910204]
- National Natural Science Foundation of China [31270808, 31300734, 31470736, 31470868, 91442125, 91542125]
- Science and Technology Commission of Shanghai Municipality [13ZR1446400]
- 'Cross and Cooperation in Science and Technology Innovation Team' project of the Chinese Academy of Sciences
- Knowledge Innovation Program of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences [2014KIP202]
Striatin-interacting phosphatase and kinase (STRIPAK) complexes are striatin-centered multicomponent supramolecular structures containing both kinases and phosphatases. STRIPAK complexes are evolutionarily conserved and have critical roles in protein (de) phosphorylation. Recent studies indicate that STRIPAK complexes are emerging mediators and regulators of multiple vital signaling pathways including Hippo, MAPK (mitogen-activated protein kinase), nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are extensively involved in a variety of fundamental biological processes ranging from cell growth, differentiation, proliferation and apoptosis to metabolism, immune regulation and tumorigenesis. Growing evidence correlates dysregulation of STRIPAK complexes with human diseases including cancer. In this review, we summarize the current understanding of the assembly and functions of STRIPAK complexes, with a special focus on cell signaling and cancer.
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