期刊
CHEMISTRY OF MATERIALS
卷 28, 期 1, 页码 146-152出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemmater.5b03445
关键词
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资金
- National Science Foundation [CHE 1011796]
- Georgia Institute of Technology
A new family of modular, fragmentable oligo- and polycations has been developed based on the reactions of 9-thiabicyclo[3.3.1]dichloride and related compounds with substituted dipyridyl nudeophiles by an anchimeric assistance mechanism. Each bond-forming event in this condensation polymerization process generates a positive charge in the main chain. Product lengths were found to be dependent on the reactivity of the electrophile, which was tunable by changing the nature of the leaving group beta to sulfur. The monomers were easily synthesized, and the resulting readily available polymers were found to be highly efficient binders of nucleic acid. They exhibited properties of cytotoxicity and DNA transfection expected of such polycationic materials, but with interesting structure-activity differences that remain to be explored. The polycations decomposed by hydrolysis at rates dependent on the leaving group ability of the pyridyl unit, which correlated roughly with the pK(a) of its conjugate acid. Polymer decomposition occurs simultaneously throughout the length of the chains, rather than from the ends; the decomposition products were tested and found to be only minimally toxic to cultured cells.
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