期刊
OCULAR IMMUNOLOGY AND INFLAMMATION
卷 24, 期 4, 页码 470-475出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/09273948.2016.1175642
关键词
Acute anterior uveitis; epidemiology; HLA-B27; iritis; spondyloarthropathy
资金
- Research to Prevent Blindness
- NTH [P30 EY010572]
- Department of Veterans Affairs
Acute anterior uveitis is generally recognized as the most common form of uveitis. An association with HLA-B27 is seen in approximately half of cases of acute anterior uveitis. The prevalence of HLA-B27 varies widely between ethnic populations, with an approximate 8-10% prevalence in non-Hispanic whites and lower prevalence in Mexican- (4%) and African- (2-4%) Americans. A group of systemic inflammatory diseases, the spondyloarthropathies, similarly demonstrates a strong association with HLA-B27. The strength of association varies, depending on the specific spondyloarthropathy, with the strongest association found in patients with ankylosing spondylitis. The majority of patients with HLA-B27 associated uveitis will have an underlying spondyloarthropathy. Suspicion for HLA-B27 associated uveitis should prompt a careful clinical history to assess for features of a spondyloarthropathy as the characteristics of any associated uveitis may vary.
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