4.3 Article

Aggressive Initial Presentation of HLA-B27 Uveitis in Older Individuals: A Case Series

期刊

OCULAR IMMUNOLOGY AND INFLAMMATION
卷 26, 期 3, 页码 425-427

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TAYLOR & FRANCIS INC
DOI: 10.1080/09273948.2016.1234626

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HLA-B27; hypopyon; older; uveitis

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Purpose: HLA-B27-associated uveitis is classically thought to be a disease of the young, with a median age of onset in the 30s. There is a paucity of literature reporting on older individuals with HLA-B27 uveitis. Here, we describe cases of HLA-B27 uveitis presenting initially at age 70.Methods: Retrospective review of patients with HLA-B27-associated uveitis that presented initially at 70 years of age.Results: Three patients were identified. All presented with aggressive inflammation (hypopyon in two cases) and two were treated for suspected endophthalmitis. All cases were controlled sufficiently with prolonged topical anti-inflammatory therapy. One patient who was lost to follow-up demonstrated one recurrence over a 3-year period.Conclusions: This series highlights the aggressive initial presentation of HLA-B27-associated uveitis in the older population, and demonstrates the favorable response, and limitation of recurrences, with topical immunosuppressive therapy.

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