期刊
CHEMISTRY OF HETEROCYCLIC COMPOUNDS
卷 51, 期 10, 页码 872-882出版社
SPRINGER
DOI: 10.1007/s10593-015-1790-6
关键词
chalcones; pyrazolines; antimicrobial activity; Michael addition; microwave irradiation
资金
- University Grants Commission, New Delhi
A series of 6-(5-aryl-4,5-dihydro-1H-pyrazol-3-yl)-2,2-dimethylchroman-7-ol and 6-(5-aryl-4,5-dihydro-1H-pyrazol-3-yl)-2,2-dimethyl-chroman-5-ol derivatives have been synthesized from the corresponding chalcones and hydrazine hydrate in the presence of sodium acetate under microwave irradiation involving the Michael addition followed by cycloaddition. All the newly synthesized 18 compounds were screened for their in vitro antimicrobial activity. Most of the compounds displayed very good to excellent antimicrobial activity in comparison to standard drugs streptomycin and nystatin.
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