期刊
OBESITY SURGERY
卷 26, 期 10, 页码 2308-2315出版社
SPRINGER
DOI: 10.1007/s11695-016-2103-6
关键词
Bariatric surgery; Type 2 diabetesmellitus; Primary care; Electronic health records; Antidiabetes drugs
类别
资金
- UK National Institutes for Health Research (NIHR) Health Services and Delivery Research programme [12/5005/12]
- NIHR Biomedical Research Centre at Guy's and St Thomas' National Health Service Foundation Trust and King's College London
- National Institute for Health Research [12/5005/12] Funding Source: researchfish
The objective of the study is to evaluate the effect of gastric banding, gastric bypass and sleeve gastrectomy on medium to long-term diabetes control in obese participants with type 2 diabetes mellitus. Matched cohort study using primary care electronic health records from the UK Clinical Practice Research Datalink. Obese participants with type 2 diabetes who received bariatric surgery from 2002 to 2014 were compared with matched control participants who did not receive BS. Remission was defined for each year of follow-up as HbA1c < 6.5 % and no antidiabetic drugs prescribed. There were 826 obese participants with T2DM who received bariatric surgery including adjustable gastric banding (LAGB) 220; gastric bypass (GBP) 449; or sleeve gastrectomy (SG) 153; with four procedures undefined. Mean HbA1c declined from 8.0 % before BS to 6.5 % in the second postoperative year; proportion with HbA1c < 6.5 % (< 48 mmol/mol) increased from 17 to 47 %. The proportion of patients in remission was 30 % in the second year, being 20 % for LAGB, 34 % for GBP and 38 % for SG. The adjusted relative rate of remission over the first six postoperative years was 5.97 (4.86 to 7.33, P < 0.001) overall; for LAGB 3.32 (2.27 to 4.86); GBP 7.16 (5.64 to 9.08); and SG 6.82 (5.05 to 9.19). Rates of remission were maintained into the sixth year of follow-up. Remission of diabetes may continue for up to 6 years after bariatric surgical procedures. Diabetes outcomes are generally more favourable after gastric bypass or sleeve gastrectomy than LAGB.
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