期刊
OBESITY
卷 24, 期 9, 页码 1874-1883出版社
WILEY
DOI: 10.1002/oby.21581
关键词
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资金
- NIH [R21 AT002617-02, UL1 TR001082, DK 048520]
- Colorado Obesity Research Institute (CORI)
- Intramural Research Program of the National Institute on Aging
Objective: To evaluate the safety and tolerability of alternate-day fasting (ADF) and to compare changes in weight, body composition, lipids, and insulin sensitivity index (Si) with those produced by a standard weight loss diet, moderate daily caloric restriction (CR). Methods: Adults with obesity (BMI >= 30 kg/m(2), age 18-55) were randomized to either zero-calorie ADF (n=14) or CR (2400 kcal/day, n=12) for 8 weeks. Outcomes were measured at the end of the 8-week intervention and after 24 weeks of unsupervised follow-up. Results: No adverse effects were attributed to ADF, and 93% completed the 8-week ADF protocol. At 8 weeks, ADF achieved a 376 kcal/day greater energy deficit; however, there were no significant betweengroup differences in change in weight (mean +/- SE; ADF -8.2 +/- 0.9 kg, CR -7.1 +/- 1.0 kg), body composition, lipids, or Si. After 24 weeks of unsupervised follow-up, there were no significant differences in weight regain; however, changes from baseline in % fat mass and lean mass were more favorable in ADF. Conclusions: ADF is a safe and tolerable approach to weight loss. ADF produced similar changes in weight, body composition, lipids, and Si at 8 weeks and did not appear to increase risk for weight regain 24 weeks after completing the intervention.
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