期刊
CHEMISTRY LETTERS
卷 44, 期 1, 页码 64-66出版社
CHEMICAL SOC JAPAN
DOI: 10.1246/cl.140879
关键词
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资金
- Japan Society for the Promotion of Science (JSPS) grant (KAKENHI) [25620126]
- JSPS Strategic Young Researcher Overseas Visits Program for Accelerating Brain Circulation program
- Grants-in-Aid for Scientific Research [25620126] Funding Source: KAKEN
In order to develop fluorescent guanine analogs having substitutions at the 7-positions, 7-(benzofuran-2-yl)-7-deazahypoxanthine (la) and 7-(benzofuran-2-yl)-7-deazaguanine (1b), were synthesized from 7-deaza-7-iodohypoxanthine and 7-deaza-7-iodo-2-N-pivaloylguanine via a Suzuki Miyaura cross-coupling, respectively. Compound 1b showed strong fluorescence, with higher fluorescent quantum yields in less polar solvents; meanwhile, la showed higher activity in more polar solvents. It is expected that the guanine analogs can be incorporated into nucleosides to develop new fluorescent oligonucleotides.
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