期刊
NUTRITIONAL NEUROSCIENCE
卷 20, 期 8, 页码 489-496出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/1028415X.2016.1186341
关键词
Diet; Polyunsaturated fat; Saturated fat; Proton magnetic resonance spectroscopy; Executive function; Memory; Aging
资金
- American Federation for Aging Research [8A0024]
- National Institutes of Health [R01 NS075565]
Objectives: Growing evidence suggests dietary factors influence cognition, but the effects of nutrient intake on cerebral metabolism in adults are currently unknown. The present study investigated the relationship between major macronutrient intake (fat, carbohydrate, and protein) and cerebral neurochemical profiles in middle-aged adults. Methods: Thirty-six adults recorded dietary intake for 3 days prior to completing cognitive testing and a proton magnetic resonance spectroscopy (H-1-MRS) scan. H-1-MRS of occipitoparietal gray matter was used to assess glutamate (Glu), N-acetyl-aspartate (NAA), choline (Cho), and myo-inositol (mI) relative to creatine (Cr) levels. Results: Regression analyses revealed that high intake of polyunsaturated fatty acids (PUFAs) was associated with lower cerebral Glu/Cr (P=0.005), and high intake of saturated fat (SFA) was associated with poorer memory function (P=0.030) independent of age, sex, education, estimated intelligence, total caloric intake, and body mass index. Discussion: In midlife, greater PUFA intake (-3 and -6) may be associated with lower cerebral glutamate, potentially indicating more efficient cellular reuptake of glutamate. SFA intake, on the other hand, was linked with poorer memory performance. These results suggest that dietary fat intake modification may be an important intervention target for the prevention of cognitive decline.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据