期刊
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
卷 26, 期 11, 页码 996-1003出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.numecd.2016.06.006
关键词
Sleep; Type 2 diabetes; Epidemiology; Prospective; Cohort
资金
- Medical Research Council UK [G9502233, G0300128]
- Cancer Research UK [C865/A2883]
- MRC [MR/N003284/1] Funding Source: UKRI
- Medical Research Council [G0401527, G1000143, MR/N003284/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0611-10084, NF-SI-0512-10114] Funding Source: researchfish
Background and aims: Few studies have prospectively examined the relationship between daytime napping and risk of type 2 diabetes. We aimed to study the effects of daytime napping and the joint effects of napping and sleep duration in predicting type 2 diabetes risk in a middle-to older-aged British population. Methods and results: In 1998-2000, 13 465 individuals with no known diabetes participating in the European Prospective Investigation into Cancer-Norfolk study reported daytime napping habit and 24-h sleep duration. Incident type 2 diabetes cases were identified through multiple data sources until 31 July 2006. After adjustment for age and sex, daytime napping was associated with a 58% higher diabetes risk. Further adjustment for education, marital status, smoking, alcohol intake, physical activity, comorbidities and hypnotic drug use had little influence on the association, but additional adjustment for BMI and Waist Circumference attenuated the Odds ratio (OR) (95% CI) to 1.30 (1.01, 1.69). The adjusted ORs (95% CI) associated with short and long sleep duration were 1.46 (1.10, 1.90) and 1.64 (1.16, 2.32), respectively. When sleep duration and daytime napping were examined together, the risk of developing diabetes more than doubled for those who took day naps and had less than 6 h of sleep, compared to those who did not nap and had 6-8 h of sleep. Conclusion: Daytime napping was associated with an increased risk of type 2 diabetes, particularly when combined with short sleep duration. Further physiological studies are needed to confirm the interaction between different domains of sleep in relation to diabetes risk. (C) 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V.
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