期刊
CHEMISTRY LETTERS
卷 44, 期 3, 页码 342-344出版社
CHEMICAL SOC JAPAN
DOI: 10.1246/cl.141035
关键词
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资金
- Funding Program for Next-Generation World-Leading Researchers
- JSPS Young Reaseach fellow program
- World Premier International Research Initiative (WPI), MEXT, Japan
- Grants-in-Aid for Scientific Research [12J07245] Funding Source: KAKEN
A crystalline protein assembly of cypovirus polyhedra was engineered to develop a carbon monoxide (CO) releasing extracellular scaffold by immobilizing ruthenium carbonyls. The molecular design includes introduction of a hexahistidine tag to the C-terminus and provides immobilization of about 2-fold more Ru carbonyls per protein monomer and effectively releases three times more CO for activation of nuclear factor kappa B (NF-kappa B) in living cells relative to wild-type polyhedra with Ru carbonyls.
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