期刊
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
卷 35, 期 10-12, 页码 670-676出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15257770.2015.1125000
关键词
lactic acid bacteria; Lactobacillus gasseri PA-3; uptake of purines
资金
- Grants-in-Aid for Scientific Research [15K16238] Funding Source: KAKEN
It is well accepted that frequent and heavy intake of purine-rich foods causes elevation of serum uric acid levels, which is a risk factor of hyperuricemia. Reducing intestinal absorption of dietary purines may attenuate the elevation of serum uric acid levels and exacerbation of hyperuricemia. This reduction may be achieved by the ingestion of lactic acid bacteria that take up purines in the intestine. In this study, we investigated the degree of uptake and utilization of purines of three lactobacilli strains. Among them, Lactobacillus gasseri PA-3 (PA-3) showed the greatest incorporation of C-14-adenine. PA-3 also incorporated C-14-adenosine and C-14-AMP. Additionally, using defined growth medium, PA-3 demonstrated greater proliferation in the presence of these purines than in their absence. Although further investigation is required, ingestion of PA-3may lower serum uric acid levels by reducing intestinal absorption of purines in humans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据