期刊
NUCLEIC ACIDS RESEARCH
卷 45, 期 D1, 页码 D104-D114出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkw888
关键词
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资金
- National Key Research and Development Plan of China [2016YFA0500803]
- National High-Tech Research and Development Program of China [2014AA021103]
- National Natural Science Foundation of China [31271402, 31522030]
- Tsinghua University Initiative Scientific Research Program [2014z21045]
- Computing Platform of National Protein Facilities (Tsinghua University)
We present POSTAR (http://POSTAR.ncrnalab.org), a resource of POST-trAnscriptional Regulation coordinated by RNA-binding proteins (RBPs). Precise characterization of post-transcriptional regulatory maps has accelerated dramatically in the past few years. Based on new studies and resources, POSTAR supplies the largest collection of experimentally probed (similar to 23 million) and computationally predicted (approximately 117 million) RBP binding sites in the human and mouse transcriptomes. POSTAR annotates every transcript and its RBP binding sites using extensive information regarding various molecular regulatory events (e.g., splicing, editing, and modification), RNA secondary structures, disease-associated variants, and gene expression and function. Moreover, POSTAR provides a friendly, multi-mode, integrated search interface, which helps users to connect multiple RBP binding sites with post-transcriptional regulatory events, phenotypes, and diseases. Based on our platform, we were able to obtain novel insights into post-transcriptional regulation, such as the putative association between CPSF6 binding, RNA structural domains, and Li-Fraumeni syndrome SNPs. In summary, POSTAR represents an early effort to systematically annotate post-transcriptional regulatory maps and explore the putative roles of RBPs in human diseases.
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