期刊
NUCLEIC ACIDS RESEARCH
卷 44, 期 8, 页码 3503-3512出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkw135
关键词
-
资金
- ERC Consolidator Grant [648050]
- EPSRC [EP/I034661/1]
- Engineering and Physical Sciences Research Council [1399404, EP/I034661/1] Funding Source: researchfish
- EPSRC [EP/I034661/1] Funding Source: UKRI
Biophysicists are modeling conformations of interphase chromosomes, often basing the strengths of interactions between segments distant on the genetic map on contact frequencies determined experimentally. Here, instead, we develop a fitting-free, minimal model: bivalent or multivalent red and green 'transcription factors' bind to cognate sites in strings of beads ('chromatin') to form molecular bridges stabilizing loops. In the absence of additional explicit forces, molecular dynamic simulations reveal that bound factors spontaneously cluster-red with red, green with green, but rarely red with green-to give structures reminiscent of transcription factories. Binding of just two transcription factors (or proteins) to active and inactive regions of human chromosomes yields rosettes, topological domains and contact maps much like those seen experimentally. This emergent 'bridging-induced attraction' proves to be a robust, simple and generic force able to organize interphase chromosomes at all scales.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据