期刊
NUCLEIC ACIDS RESEARCH
卷 44, 期 7, 页码 3190-3203出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkw034
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资金
- JSPS KAKENHI [22125001, 22125002]
- Asahi-Glass Science Foundation
- Uehara Science Foundation
- Mochida Medical Science Foundation
- Takeda Science Foundation
- Japan Society for the Promotion of Science (JSPS) through Program for Next Generation World-Leading Researchers (NEXT Program)
- National Research Foundation of Korea (NRF) - Government of Korea (MSIP) [2014R1A2A1A11051584]
- Ministry of Education, Science, Sport and Culture, JAPAN
- Grants-in-Aid for Scientific Research [22125001, 22125002, 15H05973, 26650007] Funding Source: KAKEN
- National Research Foundation of Korea [2014R1A2A1A11051584] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Meiosis-specific cohesin, required for the linking of the sister chromatids, plays a critical role in various chromosomal events during meiotic prophase I, such as chromosome morphogenesis and dynamics, as well as recombination. Rad61/Wpl1 (Wapl in other organisms) negatively regulates cohesin functions. In this study, we show that meiotic chromosome axes are shortened in the budding yeast rad61/wpl1 mutant, suggesting that Rad61/Wpl1 negatively regulates chromosome axis compaction. Rad61/Wpl1 is required for efficient resolution of telomere clustering during meiosis I, indicating a positive effect of Rad61/Wpl1 on the cohesin function required for telomere dynamics. Additionally, we demonstrate distinct activities of Rad61/Wpl1 during the meiotic recombination, including its effects on the efficient processing of intermediates. Thus, Rad61/Wpl1 both positively and negatively regulates various cohesin-mediated chromosomal processes during meiosis.
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