期刊
NUCLEIC ACIDS RESEARCH
卷 44, 期 W1, 页码 W98-W104出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkw373
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资金
- Lundbeckfonden grant for the NanoCAN Center of Excellence in Nanomedicine
- Region Syddanmarks ph.d.-pulje and Forskningspulje
- Fonden Til Laegevidenskabens Fremme, by the DAWN project - Rektorspuljen SDU program
- MIO project of the OUH Frontlinjepuljen
- VILLUM foundation by a Blokstipendiet
- el Consejo Nacional de Ciencia y Tecnologia (CONACyT) from Mexico
- CoMeDA project (Rektorspuljen SDU program)
- VILLUM Blokstipendir
- Villum Fonden [00007292] Funding Source: researchfish
We present KeyPathwayMinerWeb, the first online platform for de novo pathway enrichment analysis directly in the browser. Given a biological interaction network (e.g. protein-protein interactions) and a series of molecular profiles derived from one or multiple OMICS studies (gene expression, for instance), KeyPathwayMiner extracts connected subnetworks containing a high number of active or differentially regulated genes (proteins, metabolites) in the molecular profiles. The web interface at (http://keypathwayminer.compbio.sdu.dk) implements all core functionalities of the KeyPathwayMiner tool set such as data integration, input of background knowledge, batch runs for parameter optimization and visualization of extracted pathways. In addition to an intuitive web interface, we also implemented a REST-ful API that now enables other online developers to integrate network enrichment as a web service into their own platforms.
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