期刊
NUCLEIC ACIDS RESEARCH
卷 44, 期 5, 页码 2255-2265出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkw100
关键词
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资金
- UK Biotechnological and Biological Sciences Research Council (BBSRC)
- Institute Strategic Programme Grant 'Understanding and Exploiting Plant and Microbial Metabolism' [BB/J004561/1]
- John Innes Foundation
- Engineering and Physical Sciences Research Council (EPSRC)/National Science Foundation [EP/K03459/1]
- EPSRC/BBSRC-OpenPlant Synthetic Biology Research Centre [BB/L014130/1]
- Marie Curie Actions Fellowship
- EMBO Long-Term Fellowship
- BBSRC Institute Career Path Fellowship [BB/I019022/1]
- John Innes Centre
- BBSRC [BBS/E/J/000C0678, BB/I019022/1, BBS/E/J/000C0656, BB/L014130/1, BBS/E/J/000CA527] Funding Source: UKRI
- EPSRC [EP/K034359/1, EP/H019154/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/J/000C0678, BBS/E/J/000CA527, BB/L014130/1, BBS/E/J/00000614, BBS/E/J/000C0656, BB/I019022/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/H019154/1, EP/K034359/1] Funding Source: researchfish
Plants are a tremendous source of diverse chemicals, including many natural product-derived drugs. It has recently become apparent that the genes for the biosynthesis of numerous different types of plant natural products are organized as metabolic gene clusters, thereby unveiling a highly unusual form of plant genome architecture and offering novel avenues for discovery and exploitation of plant specialized metabolism. Here we show that these clustered pathways are characterized by distinct chromatin signatures of histone 3 lysine trimethylation (H3K27me3) and histone 2 variant H2A.Z, associated with cluster repression and activation, respectively, and represent discrete windows of co-regulation in the genome. We further demonstrate that knowledge of these chromatin signatures along with chromatin mutants can be used to mine genomes for cluster discovery. The roles of H3K27me3 and H2A.Z in repression and activation of single genes in plants are well known. However, our discovery of highly localized operon-like co-regulated regions of chromatin modification is unprecedented in plants. Our findings raise intriguing parallels with groups of physically linked multi-gene complexes in animals and with clustered pathways for specialized metabolism in filamentous fungi.
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