期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 357, 期 4, 页码 617-666出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201400904
关键词
catalysis; copper; heterocycles; molecular diversity; multicomponent reactions; synthetic methods
资金
- CLIB graduate cluster
- Fonds der Chemischen Industrie
The copper-catalyzed alkyne-azide cycloaddition (CuAAC) is a highly versatile, regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles under mild reaction conditions and has found numerous applications in medicinal, bioorganic, and materials chemistry in the past one and a half decades. By virtue of the enormous tolerance for functional groups and the mild reaction conditions, CuAAC has become increasingly important in combination with multicomponent reactions (MCR), either in a domino or in a consecutive fashion. While the majority of CuAAC-based MCR are founded on the in situ or en route generation of azides, one-pot generation of alkynes and the concatenation with other MCR are rapidly catching up and novel sequences for efficient one-pot syntheses of triazole-based structures in a multicomponent fashion are constantly evolving. This review summarizes important contributions of CuAAC-based MCR including MCR-type applications in polymer science.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据