期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 357, 期 6, 页码 1311-1315出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201400883
关键词
air; amination; C-H activation; copper; dehydrogenation
资金
- National Natural Science Foundation of China (NSFC) [21102005]
The copper(I) bromide-catalyzed intermolecular dehydrogenative amidation of arenes via C-H bond activation assisted by a 2-pyridyl or 1-pyrazolyl chelating group using air as the terminal oxidant has been achieved at 140 degrees C. N-Aryl amides, N-alkyl amides, benzamide derivatives, imides, and lactams all are good coupling partners to obtain moderate to excellent yields. The amount of solvent is critical for the transformation: both increasing and decreasing the amount of solvent decreased the yield. Notably, the amidation of bimolecular 2-phenylpyridine with the dual N-H bonds of a primary amide proceeded smoothly in one-pot to afford a good yield under the same conditions. The amidation can be performed with a good yield at the gram scale.
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