期刊
NORDIC JOURNAL OF PSYCHIATRY
卷 71, 期 3, 页码 217-222出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/08039488.2016.1265584
关键词
Major depressive disorder; depressive symptom combinations; polythetic definition; diagnostic heterogeneity; family resemblances
类别
资金
- Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea [HI10C2020]
Background: The polythetic nature of major depressive disorder (MDD) in DSM- IV and DSM-5 inevitably leads to diagnostic heterogeneity.Aims: This study aimed to identify the number of depressive symptom combinations actually fulfilling the DSM-IV diagnostic criteria that can be found in Korean MDD patients and the relative frequencies of each combination.Methods: Using the data from the Clinical Research Center for Depression (CRESCEND) study in South Korea, we enrolled 853 MDD patients diagnosed using DSM-IV and scored as 8 or more on the Hamilton Depression Rating Scale (HAMD). Descriptive statistical analyses were performed to reveal the degree of diagnostic heterogeneity of the MDD.Results: This study identified 119 different depressive symptom combinations. The most common combination consisted of all nine depressive symptom profiles, and nine different combinations were each present in more than 3% of the patients.Conclusion: The findings support the criticism that the diagnosis of MDD is not based on a single mental process, but on a set of family resemblances'.
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