期刊
NMR IN BIOMEDICINE
卷 30, 期 1, 页码 -出版社
WILEY
DOI: 10.1002/nbm.3671
关键词
brain; diffusion; macromolecule; metabolite; motion artifact; MRS; oscillating gradient
资金
- European Research Council [336331]
- European Research Council (ERC) [336331] Funding Source: European Research Council (ERC)
Measuring diffusion at ultra-short time scales may yield information about short-range intracellular structure and cytosol viscosity. However, reaching such time scales usually requires oscillating gradients, which in turn imply long echo times TE. Here we propose a new kind of stretched oscillating gradient that allows us to increase diffusion-weighting b while preserving spectral and temporal properties of the gradient modulation. We used these optimized gradients to measure metabolite diffusion in the mouse brain down to effective diffusion times of 1 ms while keeping TE relatively short (60 ms). At such TE, a significant macromolecule signal could still be observed and used as an internal reference of approximately null diffusivity, which proved critical to discard datasets corrupted by some motion artifact. The methods introduced here may be useful to improve the accuracy and precision of metabolite apparent diffusion coefficient measurements with oscillating gradients.
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