期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 357, 期 14-15, 页码 3262-3272出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201500653
关键词
asymmetric hydrogenation; RuPHOX-Ru; ruthenocenyl phosphino-oxazoline-ruthenium complex; beta-secondary amino ketones; gamma-secondary amino alcohols; synthesis
资金
- National Nature Science Foundation of China [21172143, 21172145, 21232004, 21372152]
- Nippon Chemical Industrial Co. Ltd.
- Shanghai Jiao Tong University (SJTU)
- Instrumental Analysis Center of SJTU
A ruthenocenyl phosphino-oxazoline-ruthenium complex (RuPHOX-Ru) was applied successfully to the asymmetric hydrogenation of beta-secondary amino ketones, directly affording the corresponding chiral gamma-secondary amino alcohols in up to 99% yield and with 99% ee. Reaction with beta-(benzylamino)-1-phenylpropan-1-one could be performed on a gram-scale with a relatively low catalyst loading (up to 2000 S/C). The resulting hydrogenated product could be used for the synthesis of synthetically useful compounds.
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