期刊
CHEMISTRY & BIODIVERSITY
卷 12, 期 3, 页码 371-379出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201400119
关键词
Drimane sesquiterpenoids; Sesquiterpenoids; Aspergillus oryzae; Astellolides C-I
资金
- NSFC [81121062, 21132004]
- 863 Project [2013AA092903]
Three new drimane sesquiterpenoids, astellolides C-E (1-3, resp.), four new drimane sesquiterpenoid p-hydroxybenzoates, astellolides F-I (4-7, resp.), together with two known compounds astellolides A and B (8 and 9, resp.), have been isolated from the liquid culture of Aspergillus oryzae (strain No.QXPC-4). Their structures were established by comprehensive analysis of spectroscopic data. The relative and absolute configurations were determined on the basis of NOESY and CD data, together with single-crystal X-ray diffraction analyses of compounds 1-3. The metabolites were evaluated for their cytotoxic activities, however, no compounds showed a significant cytotoxicity against the tested cell lines at a concentration of 20M.
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