期刊
CHEMISTRY & BIODIVERSITY
卷 12, 期 9, 页码 1398-1406出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201400321
关键词
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资金
- China Postdoctoral Science Foundation [2014 M560582]
- National Natural Science Foundation of China [41130858, 41322037, 81172977]
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1406402]
Six steroid derivatives, 1-6, and five butyrolactone derivatives, 7-11, were isolated from the fermentation broth of a gorgonian-derived Aspergillus sp. fungus. Their structures were elucidated on the basis of NMR and MS spectral data. Compound 1 is a new, highly conjugated steroid. The NMR and MS data of 7 and 8 are reported for the first time, as their structures were listed in SciFinder Scholar with no associated reference. Compounds 1, 4, 5, and 8-11 inhibited the larval settlement of barnacle Balanus amphitrite with EC50 values ranging from 0.63 to 18.4 mu g ml(-1). Butyrolactone derivatives 7 and 8 showed pronounced antibacterial activities against Staphylococcus aureus with the same MIC values as the positive control ciprofloxacin (MIC 1.56 mu M for all three compounds).
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