☆ 4.0 Review

Animal Models of Kidney Disease: Challenges and Perspectives

KIDNEY360 (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Medicine, General & Internal

Review of the Use of Animal Models of Human Polycystic Kidney Disease for the Evaluation of Experimental Therapeutic Modalities

Shizuko Nagao et al.

Summary: Autosomal dominant polycystic kidney disease, autosomal recessive polycystic kidney disease, and nephronophthisis are hereditary disorders characterized by multiple cysts in both kidneys, leading to chronic and end-stage renal failure. Animal models have been instrumental in advancing our understanding of disease mechanisms and developing therapeutic interventions. Genetically modified models, created using genetic and reproductive engineering techniques, have taken over as the primary focus of research after the identification of responsible genes. This review highlights murine models of hereditary renal cystic diseases and their potential contribution to therapeutic strategies.

JOURNAL OF CLINICAL MEDICINE (2023)

添加到收藏夹

Article Medicine, Research & Experimental

Insulin-like growth factor 2 mRNA-binding protein 3 promotes kidney injury by regulating β-catenin signaling

Dongyan Song et al.

Summary: The study reveals that IGF2BP3 plays a crucial role in regulating beta-catenin. IGF2BP3 is upregulated in renal tubular epithelium of various animal models and patients with chronic kidney disease. IGF2BP3 is not only a direct downstream target of Wnt/beta-catenin but also an obligatory factor for transducing Wnt signal.

JCI INSIGHT (2023)

添加到收藏夹

Article Physiology

Unilateral Nephrectomized SHR/NDmcr-cp Rat Shows a Progressive Decline of Glomerular Filtration With Tubular Interstitial Lesions

Yuichi Shinozaki et al.

Summary: In patients with diabetic kidney disease (DKD), there is a need for animal models to evaluate renal function decline and assess the efficacy of therapeutic agents. This study developed a DKD animal model using spontaneously hypertensive rat (SHR)/NDmcr-cp (cp/cp) rats with characteristics of obese type 2 diabetes. Unilateral nephrectomy (UNx) in these rats resulted in a decline in creatinine clearance rate (Ccr), glomerular sclerosis, tubular lesions, and tubulointerstitial fibrosis, accompanied by renal anemia. Treatment with losartan-mixed diet suppressed Ccr decline, improved renal anemia and histopathological changes. These findings suggest that UNx-SHR/cp rats can be used as a DKD model for evaluating therapeutic agents.

PHYSIOLOGICAL RESEARCH (2023)

添加到收藏夹

Article Endocrinology & Metabolism

Sex- and age-related differences in renal and cardiac injury and senescence in stroke-prone spontaneously hypertensive rats

Aneesa Ansari et al.

Summary: Sex differences play a critical role in cardiovascular diseases, with men at higher risk than premenopausal women. This study analyzed sex differences in hypertensive cardiac and renal injury in middle-aged SHRSP rats to determine the interaction between age, sex, and cell senescence. The results showed that male rats had greater levels of fibrosis and cellular senescence in the kidney compared to females, indicating a clear sex pattern in age-related progression of organ damage.

BIOLOGY OF SEX DIFFERENCES (2023)

添加到收藏夹

Review Endocrinology & Metabolism

Translation Animal Models of Diabetic Kidney Disease: Biochemical and Histological Phenotypes, Advantages and Limitations

Wenting Luo et al.

Summary: Animal models play a vital role in understanding diseases, developing drugs, identifying risk markers, and improving prevention and treatment methods. However, creating a model for diabetic kidney disease (DKD) has been challenging. Although several models have been created, none truly encompass all the important aspects of human DKD. Choosing the appropriate model is crucial, as different models develop different characteristics and have limitations. This paper provides a comprehensive overview of DKD animal models, including phenotypes, modeling mechanisms, advantages, and limitations, in order to update model information and guide the selection of suitable models for different research needs.

DIABETES METABOLIC SYNDROME AND OBESITY (2023)

添加到收藏夹

Article Urology & Nephrology

International Society of Nephrology first consensus guidance for preclinical animal studies in translational nephrology

Masaomi Nangaku et al.

Summary: The International Society of Nephrology organized the TRANSFORM meeting to provide guidance on translational animal studies for new drug development in kidney disease. The meeting covered various themes such as disease model selection, pharmacokinetics, interventions, choice of animal, statistical power, organoids and organ-on-a-chip models, and reporting of results. These recommendations aim to accelerate the development of new drugs for efficacious diseases.

KIDNEY INTERNATIONAL (2023)

添加到收藏夹

Article Medicine, Research & Experimental

The STAT1/HMGB1/NF-?B pathway in chronic inflammation and kidney injury after cisplatin exposure

Ying Fu et al.

Summary: This study uncovers the role of the STAT1/HMGB1/NF-?B pathway in chronic kidney problems after long-term use of cisplatin, providing new therapeutic targets for kidney protection in cancer patients receiving cisplatin chemotherapy.

THERANOSTICS (2023)

添加到收藏夹

Article Veterinary Sciences

Genetic background strongly influences the transition to chronic kidney disease of adriamycin nephropathy in mice

Masaki Watanabe et al.

Summary: Animal models are useful for studying podocytopathy and chronic kidney diseases. ADR-induced nephropathy in rodents is a common model for podocytopathy. A new strain of mutant B6 mice with ADR nephropathy was developed and found to progress to CKD. Comparisons with BALB/c mice revealed genetic background differences related to inflammatory mediators and further analysis is needed.

EXPERIMENTAL ANIMALS (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Glutamine alleviates the renal dysfunction associated with gentamicin-induced acute kidney injury in Sprague-Dawley rats

Feng Zhan et al.

Summary: Sepsis is a life-threatening clinical condition caused by infection, with a high mortality rate. Glutamine supplementation shows therapeutic potential in attenuating gentamicin-induced acute kidney injury and reducing oxidative stress in sepsis patients.

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling

Qian Yuan et al.

Summary: Loss of Klotho protein is involved in the development of chronic kidney diseases. Researchers have discovered a peptide called KP1 derived from Klotho protein that protects the kidneys by targeting the TGF-beta signaling pathway. KP1 inhibits TGF-beta signaling, prevents fibrosis, and improves kidney function.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Medicine, Research & Experimental

CXCR4 induces podocyte injury and proteinuria by activating β-catenin signaling

Hongyan Mo et al.

Summary: This study found that CXCR4 and beta-catenin colocalized in glomerular podocytes and that the assembly of CXCR4/beta-arrestin-1/Src signalosome led to beta-catenin activation, promoting podocyte dysfunction and proteinuria.

THERANOSTICS (2022)

添加到收藏夹

Article Urology & Nephrology

Drug-Induced Acute Kidney Injury

Mark A. Perazella et al.

Summary: Medications can cause acute kidney injury (AKI) through direct tubular injury, induction of inflammation, and crystalline deposition. Clinicians should understand the pathogenesis of these forms of kidney injury for prevention and treatment.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

添加到收藏夹

Review Urology & Nephrology

The impact of genetic background on mouse models of disease

Rei Bufi et al.

Summary: The mouse is commonly used to study kidney disease, but genetic background differences and effects need to be considered. Choosing the right mouse strain can improve translational research and make the results more applicable to humans. Using genetically diverse mice can provide results that better reflect the variation in human disease outcomes. Therefore, embracing the genetic diversity in mice is important for better translational research methods.

KIDNEY INTERNATIONAL (2022)

添加到收藏夹

Article Urology & Nephrology

Klotho-derived peptide 6 ameliorates diabetic kidney disease by targeting Wnt/beta-catenin signaling

Xiaowen Chen et al.

Summary: The Klotho-derived peptide KP6 mimics the protective effects of Klotho in diabetic kidney disease, alleviating established proteinuria, glomerular hypertrophy, podocyte damage, glomerulosclerosis, and interstitial fibrotic lesions by blocking the Wnt/beta-catenin signaling pathway.

KIDNEY INTERNATIONAL (2022)

添加到收藏夹

Review Urology & Nephrology

Drosophila melanogaster: a simple genetic model of kidney structure, function and disease

Julian A. T. Dow et al.

Summary: The fruitfly Drosophila melanogaster serves as a suitable and cost-effective model for studying kidney diseases. It has advantages such as easy maintenance, availability of genetic mutants and powerful transgenic technologies. Various tissues in Drosophila melanogaster are involved in renal and excretory functions, allowing investigation of epithelial transport, kidney stone formation, and diseases associated with specific genes. The fly model provides insights into the mechanisms of kidney disease.

NATURE REVIEWS NEPHROLOGY (2022)

添加到收藏夹

Article Cell Biology

Modeling injury and repair in kidney organoids reveals that homologous recombination governs tubular intrinsic repair

Navin Gupta et al.

Summary: Kidneys have the capacity for intrinsic repair, but when overwhelmed, incomplete repair can lead to chronic kidney disease. Limited treatments exist due to the limited predictivity of animal studies. This study used kidney organoids to identify genes and pathways involved in intrinsic repair and discovered a potential therapeutic candidate that can prevent the progression of chronic kidney disease.

SCIENCE TRANSLATIONAL MEDICINE (2022)

添加到收藏夹

Review Urology & Nephrology

Epidemiology of chronic kidney disease: an update 2022

Csaba P. Kovesdy

Summary: Chronic kidney disease affects over 800 million individuals worldwide, especially prevalent in older individuals, women, racial minorities, and people with diabetes and hypertension. It has become a major cause of mortality globally, particularly in low- and middle-income countries.

KIDNEY INTERNATIONAL SUPPLEMENTS (2022)

添加到收藏夹

Review Cell Biology

Studying Kidney Diseases Using Organoid Models

Meng Liu et al.

Summary: The prevalence of chronic kidney disease is increasing, driving the need for new therapeutic approaches. Three-dimensional kidney organoid models, generated from stem cells and cell cultures, have been successfully developed. These models provide valuable tools for studying kidney diseases and finding solutions.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

添加到收藏夹

Editorial Material Urology & Nephrology

Modelling AKI in vitro: taking organoids to the next level

Letizia De Chiara et al.

KIDNEY INTERNATIONAL (2022)

添加到收藏夹

Review Urology & Nephrology

The fibrogenic niche in kidney fibrosis: components and mechanisms

Li Li et al.

Summary: Kidney fibrosis, the final outcome of chronic kidney diseases, is characterized by excessive deposition of extracellular matrix (ECM). The fibrogenic niche, a unique tissue microenvironment, plays a crucial role in promoting fibroblast activation and organ fibrosis. Understanding the composition and mechanisms of the fibrogenic niche may lead to the development of non-invasive biomarkers and novel therapies for kidney diseases.

NATURE REVIEWS NEPHROLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Single-cell analyses of axolotl telencephalon organization, neurogenesis, and regeneration

Katharina Lust et al.

Summary: This study used single-cell genomic profiling to investigate the cell populations in the axolotl brain, revealing similarities to neurons in other amniotes. The research also provided insights into the transcriptional dynamics and gene regulatory relationships during regeneration, as well as identifying conserved differentiation features.

SCIENCE (2022)

添加到收藏夹

Review Chemistry, Analytical

Kidney-on-a-Chip: Mechanical Stimulation and Sensor Integration

Dan Wang et al.

Summary: Bioengineered kidney-on-a-chip models provide a means to mimic the in vivo microenvironment of the kidney and study kidney physiology and disease models. Incorporating mechanical stimuli and sensor integration are crucial for replicating the physiological and pathological conditions.

SENSORS (2022)

添加到收藏夹

Review Cell Biology

Assessing kidney development and disease using kidney organoids and CRISPR engineering

Wajima Safi et al.

Summary: The differentiation of human pluripotent stem cells towards kidney organoids has advanced regenerative medicine significantly. Understanding the developmental pathways of nephrogenesis has enabled the in vitro recapitulation of kidney development. Genome editing approaches, such as CRISPR/Cas9 technology, have provided insights into specific gene functions during renal differentiation from hPSCs.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

添加到收藏夹

Review Physiology

Comparison of the surgical resection and infarct 5/6 nephrectomy rat models of chronic kidney disease

Ryan J. Adam et al.

Summary: The 5/6 nephrectomy rat remnant kidney model is commonly used in studying chronic kidney disease (CKD). This model has similarities and differences in phenotypic characteristics compared to human CKD. Both models show hallmarks of CKD, but also have unique vascular phenotypes. Understanding these models can provide insights into studying CKD pathophysiology.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2022)

添加到收藏夹

Article Urology & Nephrology

Drug-Induced Hospital-Acquired Acute Kidney Injury in China: A Multicenter Cross-Sectional Survey

Chen Liu et al.

Summary: This study investigated the disease burden, related drugs, and risk factors of D-AKI in China, revealing a substantial medical burden associated with D-AKI, with a high mortality rate and low recovery rate among patients. Efforts should be made to manage nephrotoxic drugs and improve prevention, diagnosis, and treatment of D-AKI.

KIDNEY DISEASES (2021)

添加到收藏夹

Correction Cell Biology

The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease (vol 33, 1.e1, 2021)

Han Zhu et al.

CELL METABOLISM (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Method used to establish a large animal model of drug-induced acute kidney injury

Si-Yang Wang et al.

Summary: Acute kidney injury is a serious health hazard disease with complex etiology and lack of effective treatments, leading to high medical costs and high mortality. Mini pigs are ideal animals to model kidney disease due to their similar kidney anatomy and morphology to humans, better representing acute kidney injury caused by antibiotics and chemotherapeutic drugs.

EXPERIMENTAL BIOLOGY AND MEDICINE (2021)

添加到收藏夹

Article Cell Biology

Mechanism and reversal of drug-induced nephrotoxicity on a chip

Aaron Cohen et al.

Summary: The kidney is crucial for maintaining fluid balance, glucose control, and drug excretion, but drug-induced nephrotoxicity can lead to kidney dysfunction. Research shows that certain drugs disrupt proximal tubule polarity at subtoxic concentrations, causing issues. By inhibiting glucose reabsorption, the adverse effects of drugs can be significantly reduced.

SCIENCE TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Review Medicine, General & Internal

Chronic kidney disease

Kamyar Kalantar-Zadeh et al.

Summary: Chronic kidney disease is a progressive disease with no cure, and preserving kidney function through lifestyle adjustments and pharmacological interventions can improve outcomes. A plant-dominant, low-protein, and low-salt diet may help mitigate glomerular hyperfiltration and preserve renal function. Various pharmacotherapies can also be used to alter intrarenal haemodynamics and protect the kidney from further damage.

LANCET (2021)

添加到收藏夹

Article Medicine, General & Internal

Acute kidney injury

John A. Kellum et al.

Summary: Acute kidney injury (AKI) describes a sudden loss of kidney function which can lead to long term damage. AKI and AKD are global issues with different causes and management strategies in various regions. Prevention and early detection of AKI are crucial for better outcomes.

NATURE REVIEWS DISEASE PRIMERS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Folic acid-induced animal model of kidney disease

Liang-Jun Yan

Summary: The kidneys are vulnerable to both acute kidney injury (AKI) and chronic kidney disease (CKD), with animal models being crucial for studying the pathological mechanisms of kidney disease. This article reviews a widely used animal model of kidney disease induced by folic acid (FA), discussing the major mechanisms of FA-induced kidney injury and its application in testing therapeutic approaches.

ANIMAL MODELS AND EXPERIMENTAL MEDICINE (2021)

添加到收藏夹

Review Medicine, General & Internal

Coagulation, Protease-Activated Receptors, and Diabetic Kidney Disease: Lessons from eNOS-Deficient Mice

Yuji Oe et al.

Summary: Dysfunction of endothelial nitric oxide synthase (eNOS) worsens the progression of diabetic kidney disease (DKD) by promoting hypercoagulability, which results in kidney injury. Inhibiting or genetically deleting coagulation factors or PARs can ameliorate inflammation in DKD patients.

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE (2021)

添加到收藏夹

Article Developmental Biology

Methods to generate and evaluate zebrafish models of human kidney diseases

Sana Fatma et al.

Summary: Kidney-related disorders impact millions globally, with CKD ranking 12th in global causes of death.The use of model organisms like zebrafish aids in understanding and potentially treating human kidney diseases. Genetic and experimental manipulations in zebrafish may advance therapeutic development for kidney diseases.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (2021)

添加到收藏夹

Article Medicine, General & Internal

Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Boris Bikbov et al.

LANCET (2020)

添加到收藏夹

Article Toxicology

Adult Zebrafish Model for Screening Drug -Induced Kidney Injury

Yuki Kato et al.

TOXICOLOGICAL SCIENCES (2020)

添加到收藏夹

Review Urology & Nephrology

Targeting the progression of chronic kidney disease

Marta Ruiz-Ortega et al.

NATURE REVIEWS NEPHROLOGY (2020)

添加到收藏夹

Review Urology & Nephrology

AKI: an increasingly recognized risk factor for CKD development and progression

J. T. Kurzhagen et al.

JOURNAL OF NEPHROLOGY (2020)

添加到收藏夹

Article Urology & Nephrology

Gentamicin-Induced Acute Kidney Injury in an Animal Model Involves Programmed Necrosis of the Collecting Duct

Huihui Huang et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2020)

添加到收藏夹

Review Medicine, Research & Experimental

Renal ischemia/reperfusion injury: An insight on in vitro and in vivo models

Niharika Shiva et al.

LIFE SCIENCES (2020)

添加到收藏夹

Article Medicine, General & Internal

Dapagliflozin in Patients with Chronic Kidney Disease

Hiddo J. L. Heerspink et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Article Medicine, General & Internal

Recommendations on Acute Kidney Injury Biomarkers From the Acute Disease Quality Initiative Consensus Conference A Consensus Statement

Marlies Ostermann et al.

JAMA NETWORK OPEN (2020)

添加到收藏夹

Review Primary Health Care

Diabetic Kidney Disease

Ryan Bonner et al.

PRIMARY CARE (2020)

添加到收藏夹

Article Physiology

Evaluation of cisplatin-induced injury in human kidney organoids

Jenny L. M. Digby et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2020)

添加到收藏夹

Review Pediatrics

Zebrafish as a model for kidney function and disease

Priya Outtandy et al.

PEDIATRIC NEPHROLOGY (2019)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Tubuloids derived from human adult kidney and urine for personalized disease modeling

Frans Schutgens et al.

NATURE BIOTECHNOLOGY (2019)

添加到收藏夹

Review Medicine, General & Internal

Organoids - Preclinical Models of Human Disease

Mo Li et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

添加到收藏夹

Article Urology & Nephrology

Matching Human Unilateral AKI, a Reverse Translational Approach to Investigate Kidney Recovery after Ischemia

Danielle E. Soranno et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Metabolomic and biochemical characterization of a new model of the transition of acute kidney injury to chronic kidney disease induced by folic acid

Marlene Marisol Perales-Quintana et al.

PEERJ (2019)

添加到收藏夹

Review Medicine, General & Internal

Acute kidney injury

Claudio Ronco et al.

LANCET (2019)

添加到收藏夹

Article Urology & Nephrology

Long-term risk of adverse outcomes after acute kidney injury: a systematic review and meta-analysis of cohort studies using consensus definitions of exposure

Emily J. See et al.

KIDNEY INTERNATIONAL (2019)

添加到收藏夹

Article Urology & Nephrology

Reversal Unilateral Ureteral Obstruction: A Mice Experimental Model

Alonso Narvaez Barros et al.

NEPHRON (2019)

添加到收藏夹

Article Veterinary Sciences

Establishment of renal failure models by laparoscopy in bama pigs which underwent partial nephrectomy and radical contralateral nephrectomy

Hai-Feng Liu et al.

JOURNAL OF VETERINARY RESEARCH (2019)

添加到收藏夹

Review Urology & Nephrology

Mechanisms and therapeutic targets of ischemic acute kidney injury

Sang Jun Han et al.

KIDNEY RESEARCH AND CLINICAL PRACTICE (2019)

添加到收藏夹

Article Physiology

Chronic effects of repeated low-dose cisplatin treatment in mouse kidneys and renal tubular cells

Ying Fu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2019)

添加到收藏夹

Article Urology & Nephrology

Pharmacology behind Common Drug Nephrotoxicities

Mark A. Perazella

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

A new model of diabetic nephropathy in C57BL/6 mice challenged with advanced oxidation protein products

Xiaoyan Bai et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

添加到收藏夹

Article Multidisciplinary Sciences

An essential role for Wnt/β-catenin signaling in mediating hypertensive heart disease

Yue Zhao et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

The axolotl genome and the evolution of key tissue formation regulators

Sergej Nowoshilow et al.

NATURE (2018)

添加到收藏夹

Review Urology & Nephrology

Global epidemiology and outcomes of acute kidney injury

Eric A. J. Hoste et al.

NATURE REVIEWS NEPHROLOGY (2018)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Cisplatin-Induced Rodent Model of Kidney Injury: Characteristics and Challenges

Martina Perse et al.

BIOMED RESEARCH INTERNATIONAL (2018)

添加到收藏夹

Article Medicine, General & Internal

Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016-40 for 195 countries and territories

Kyle J. Foreman et al.

LANCET (2018)

添加到收藏夹

Review Physiology

Rodent models of AKI-CKD transition

Ying Fu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2018)

添加到收藏夹

Article Physiology

A translational model of chronic kidney disease in swine

Alejandro R. Chade et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2018)

添加到收藏夹

Article Immunology

Early Phase Mast Cell Activation Determines the Chronic Outcome of Renal Ischemia-Reperfusion Injury

Luca Danelli et al.

JOURNAL OF IMMUNOLOGY (2017)

添加到收藏夹

Article Biochemical Research Methods

A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice

Li Wang et al.

LAB ON A CHIP (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Restored nitric oxide bioavailability reduces the severity of acute-to-chronic transition in a mouse model of aristolochic acid nephropathy

Ines Jadot et al.

PLOS ONE (2017)

添加到收藏夹

Article Urology & Nephrology

Diabetic Kidney Disease Challenges, Progress, and Possibilities

Radica Z. Alicic et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

添加到收藏夹

Article Urology & Nephrology

A Phase 2, Double-Blind, Placebo-Controlled, Randomized Study of Fresolimumab in Patients With Steroid-Resistant Primary Focal Segmental Glomerulosclerosis

Flavio Vincenti et al.

KIDNEY INTERNATIONAL REPORTS (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

The changes in glucose metabolism and cell proliferation in the kidneys of polycystic kidney disease mini-pig models

Xiaoying Lian et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

添加到收藏夹

Review Peripheral Vascular Disease

DOCA-Salt Hypertension: an Update

Tyler Basting et al.

CURRENT HYPERTENSION REPORTS (2017)

添加到收藏夹

Article Urology & Nephrology

Long-term response to renal ischaemia in the human kidney after partial nephrectomy: results from a prospective clinical trial

George J. S. Kallingal et al.

BJU INTERNATIONAL (2016)

添加到收藏夹

Article Urology & Nephrology

Sustained Activation of Wnt/β-Catenin Signaling Drives AKI to CKD Progression

Liangxiang Xiao et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

添加到收藏夹

Review Biochemistry & Molecular Biology

Modeling Development and Disease with Organoids

Hans Clevers

CELL (2016)

添加到收藏夹

Article Immunology

Consistency and pathophysiological characterization of a rat polymicrobial sepsis model via the improved cecal ligation and puncture surgery

Xin Liu et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Unilateral Renal Ischemia-Reperfusion as a Robust Model for Acute to Chronic Kidney Injury in Mice

Nathalie Le Clef et al.

PLOS ONE (2016)

添加到收藏夹

Article Multidisciplinary Sciences

GDF11 improves tubular regeneration after acute kidney injury in elderly mice

Ying Zhang et al.

SCIENTIFIC REPORTS (2016)

添加到收藏夹

Article Physiology

Repeated administration of low-dose cisplatin in mice induces fibrosis

Cierra N. Sharp et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2016)

添加到收藏夹

Article Critical Care Medicine

Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study

Eric A. J. Hoste et al.

INTENSIVE CARE MEDICINE (2015)

添加到收藏夹

Article Urology & Nephrology

Protective effects of edaravone, a free radical scavenger, on lipopolysaccharide-induced acute kidney injury in a rat model of sepsis

Lin Liu et al.

INTERNATIONAL UROLOGY AND NEPHROLOGY (2015)

添加到收藏夹

Article Urology & Nephrology

Extracellular Superoxide Dismutase Protects against Proteinuric Kidney Disease

Roderick J. Tan et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Nephron organoids derived from human pluripotent stem cells model kidney development and injury

Ryuji Morizane et al.

NATURE BIOTECHNOLOGY (2015)

添加到收藏夹

Article Urology & Nephrology

Severe Renal Mass Reduction Impairs Recovery and Promotes Fibrosis after AKI

Aaron J. Polichnowski et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

添加到收藏夹

Review Medicine, General & Internal

Acute Kidney Injury and Chronic Kidney Disease as Interconnected Syndromes

Lakhmir S. Chawla et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Synchronized renal tubular cell death involves ferroptosis

Andreas Linkermann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

添加到收藏夹

Article Toxicology

Suppressed mitochondrial biogenesis in folic acid-induced acute kidney injury and early fibrosis

L. Jay Stallons et al.

TOXICOLOGY LETTERS (2014)

添加到收藏夹

Article Cell & Tissue Engineering

Mesenchymal stem cells ameliorate rhabdomyolysis-induced acute kidney injury via the activation of M2 macrophages

Yanqiu Geng et al.

STEM CELL RESEARCH & THERAPY (2014)

添加到收藏夹

Article Physiology

Ischemia-reperfusion induces renal tubule pyroptosis via the CHOP-caspase-11 pathway

Ju-Rong Yang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2014)

添加到收藏夹

Editorial Material Urology & Nephrology

KDOQI US Commentary on the 2012 KDIGO Clinical Practice Guideline for Acute Kidney Injury

Paul M. Palevsky et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2013)

添加到收藏夹

Article Urology & Nephrology

World Incidence of AKI: A Meta-Analysis

Paweena Susantitaphong et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2013)

添加到收藏夹

Review Urology & Nephrology

Bidirectional relationships between acute kidney injury and chronic kidney disease

Neesh Pannu

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2013)

添加到收藏夹

Article Urology & Nephrology

Tolerance of the Human Kidney to Isolated Controlled Ischemia

Dipen J. Parekh et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Increased Cellular Senescence and Vascular Rarefaction Exacerbate the Progression of Kidney Fibrosis in Aged Mice Following Transient Ischemic Injury

Meghan E. Clements et al.

PLOS ONE (2013)

添加到收藏夹

Article Urology & Nephrology

Arginine and Asymmetric Dimethylarginine in Puromycin Aminonucleoside-Induced Chronic Kidney Disease in the Rat

Gin-Fu Chen et al.

AMERICAN JOURNAL OF NEPHROLOGY (2012)

添加到收藏夹

Review Veterinary Sciences

Animal Models for Human Polycystic Kidney Disease

Shizuko Nagao et al.

EXPERIMENTAL ANIMALS (2012)

添加到收藏夹

Review Physiology

Mouse model of ischemic acute kidney injury: technical notes and tricks

Qingqing Wei et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2012)

添加到收藏夹

Article Critical Care Medicine

The role of renal hypoperfusion in development of renal microcirculatory dysfunction in endotoxemic rats

Matthieu Legrand et al.

INTENSIVE CARE MEDICINE (2011)

添加到收藏夹

Article Medicine, Research & Experimental

Cellular pathophysiology of ischemic acute kidney injury

Joseph V. Bonventre et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

添加到收藏夹

Article Urology & Nephrology

A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis

Howard Trachtman et al.

KIDNEY INTERNATIONAL (2011)

添加到收藏夹

Review Urology & Nephrology

Pathophysiology of ischemic acute kidney injury

Asif A. Sharfuddin et al.

NATURE REVIEWS NEPHROLOGY (2011)

添加到收藏夹

Review Urology & Nephrology

Adriamycin nephropathy: A model of focal segmental glomerulosclerosis

Vincent W. S. Lee et al.

NEPHROLOGY (2011)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cecal ligation and puncture: the gold standard model for polymicrobial sepsis?

Lien Dejager et al.

TRENDS IN MICROBIOLOGY (2011)

添加到收藏夹

Article Physiology

Acute unilateral ischemic renal injury induces progressive renal inflammation, lipid accumulation, histone modification, and end-stage kidney disease

Richard A. Zager et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2011)

添加到收藏夹

Article Urology & Nephrology

BTBR Ob/Ob Mutant Mice Model Progressive Diabetic Nephropathy

Kelly L. Hudkins et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2010)

添加到收藏夹

Article Hematology

Elevated tissue factor expression contributes to exacerbated diabetic nephropathy in mice lacking eNOS fed a high fat diet

F. Li et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2010)

添加到收藏夹

Article Urology & Nephrology

Angiotensin II overcomes strain-dependent resistance of rapid CKD progression in a new remnant kidney mouse model

Asada Leelahavanichkul et al.

KIDNEY INTERNATIONAL (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

Li Yang et al.

NATURE MEDICINE (2010)

添加到收藏夹

Review Pharmacology & Pharmacy

Gentamicin-induced nephrotoxicity: Do we have a promising therapeutic approach to blunt it?

Pitchai Balakumar et al.

PHARMACOLOGICAL RESEARCH (2010)

添加到收藏夹

Article Physiology

Influence of genetic background on albuminuria and kidney injury in Ins2+/C96Y (Akita) mice

Susan B. Gurley et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2010)

添加到收藏夹

Review Medicine, Research & Experimental

Animal models of sepsis and sepsis-induced kidney injury

Kent Doi et al.

JOURNAL OF CLINICAL INVESTIGATION (2009)

添加到收藏夹

Article Urology & Nephrology

Wnt/β-Catenin Signaling Promotes Podocyte Dysfunction and Albuminuria

Chunsun Dai et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)

添加到收藏夹

Review Urology & Nephrology

Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy

Robert L. Chevalier et al.

KIDNEY INTERNATIONAL (2009)

添加到收藏夹

Article Biochemical Research Methods

Immunodesign of experimental sepsis by cecal ligation and puncture

Daniel Rittirsch et al.

NATURE PROTOCOLS (2009)

添加到收藏夹

Article Physiology

Expression and modulation of translocator protein and its partners by hypoxia reoxygenation or ischemia and reperfusion in porcine renal models

Frederic Favreau et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2009)

添加到收藏夹

Article Medicine, Research & Experimental

Diabetic eNOS knockout mice develop distinct macro- and microvascular complications

Sumathy Mohan et al.

LABORATORY INVESTIGATION (2008)

添加到收藏夹

Article Rheumatology

Mapping similarities in mTOR pathway perturbations in mouse lupus nephritis models and human lupus nephritis

Padmalatha S. Reddy et al.

ARTHRITIS RESEARCH & THERAPY (2008)

添加到收藏夹

Article Urology & Nephrology

Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice

Hui John Zhao et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)

添加到收藏夹

Article Urology & Nephrology

Protective role of selectin ligand inhibition in a large animal model of kidney ischemia-reperfusion injury

C. Jayle et al.

KIDNEY INTERNATIONAL (2006)

添加到收藏夹

Article Urology & Nephrology

Role of caspases on cell death, inflammation, and cell cycle in glycerol-induced acute renal failure

E Homsi et al.

KIDNEY INTERNATIONAL (2006)

添加到收藏夹

Article Endocrinology & Metabolism

Characterization of susceptibility of inbred mouse strains to diabetic nephropathy

ZH Qi et al.

DIABETES (2005)

添加到收藏夹

Article Urology & Nephrology

Intravenous administration of hepatocyte growth factor gene ameliorates diabetic nephropathy in mice

CS Dai et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2004)

添加到收藏夹

Article Endocrinology & Metabolism

Development of late-stage diabetic nephropathy in OVE26 diabetic mice

SR Zheng et al.

DIABETES (2004)

添加到收藏夹

Article Transplantation

Important role for macrophages in induction of crescentic anti-GBM glomerulonephritis in WKY rats

M Isome et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2004)

添加到收藏夹

Article Urology & Nephrology

Gene expression profiling of anti-GBM glomerulonephritis model:: The role of NF-κB in immune complex kidney disease

JH Kim et al.

KIDNEY INTERNATIONAL (2004)

添加到收藏夹

Article Physiology

Coagulation in the mesangial area promotes ECM accumulation through factor V expression in MsPGN in rats

N Liu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2004)

添加到收藏夹

Review Physiology

Diabetic kidney disease in the db/db mouse

K Sharma et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2003)

添加到收藏夹

Review Urology & Nephrology

Animal models of FSGS: Lessons for pathogenesis and treatment

AB Fogo

SEMINARS IN NEPHROLOGY (2003)

添加到收藏夹

Article Urology & Nephrology

Intraperitoneal protein injection in the axolotl: The amphibian kidney as a novel model to study tubulointerstitial activation

ML Gross et al.

KIDNEY INTERNATIONAL (2002)

添加到收藏夹

Article Immunology

Acute renal failure in endotoxemia is caused by TNF acting directly on TNF receptor-1 in kidney

PN Cunningham et al.

JOURNAL OF IMMUNOLOGY (2002)

添加到收藏夹

Article Medicine, Research & Experimental

Podocyte injury promotes progressive nephropathy in Zucker diabetic fatty rats

S Hoshi et al.

LABORATORY INVESTIGATION (2002)

添加到收藏夹

Article Transplantation

Glomerular function and morphology in puromycin aminonucleoside nephropathy in rats

EKM Löwenborg et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2000)

添加到收藏夹

Article Urology & Nephrology

Complement is activated in kidney by endotoxin but does not cause the ensuing acute renal failure

PN Cunningham et al.

KIDNEY INTERNATIONAL (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.