Tuning catalyst performance in asymmetric carbene transfer toward CF3-cyclopropenes

Review Chemistry, Multidisciplinary

Biological Utility of Fluorinated Compounds: from Materials Design to Molecular Imaging, Therapeutics and Environmental Remediation

Cheng Zhang et al.

Summary: This review discusses the applications of fluorinated molecules in bioengineering and nanotechnology, with a focus on controlling fluorine-fluorine interactions and understanding their impact on biological behavior. The controlled introduction of fluorine and its interactions can provide advantages in imaging, therapeutics, and environmental applications.

CHEMICAL REVIEWS (2022)

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Article Chemistry, Physical

Fluoroalkyl N-Triftosylhydrazones as Easily Decomposable Diazo Surrogates for Asymmetric [2+1] Cycloaddition: Synthesis of Chiral Fluoroalkyl Cyclopropenes and Cyclopropanes

Xinyu Zhang et al.

Summary: The development of asymmetric [2+1] cycloadditions using fluoroalkyl-aryl ketone N-triftosylhydrazones as diazo surrogates provides high yields and enantioselectivity, with broad functional group tolerance. The products obtained feature a unique fluoroalkyl chiral quaternary carbon center. The origin of enantioselectivity was rationalized by density functional theory calculations.

ACS CATALYSIS (2021)

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Article Chemistry, Multidisciplinary