☆ 4.1 Review

Biomaterial-Based Gene Delivery to Central Nervous System Cells for the Treatment of Spinal Cord Injury

ADVANCED NANOBIOMED RESEARCH (2023)

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Summary: Nucleic acid-based therapeutic molecules have great potential for treating diseases in the CNS, but delivering them to the brain's target cells and sub-cellular compartments is a challenge. This review discusses the challenges and recent advances in cellular and sub-cellular delivery using various mechanisms and routes of administration.

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Molecular Mechanisms and Clinical Application of Multipotent Stem Cells for Spinal Cord Injury

Michal Szymoniuk et al.

Summary: Spinal Cord Injury (SCI) is a common neurological disorder that causes permanent disability in most patients. Stem Cell Therapy (SCT) shows promise in regenerating the injured spinal cord through the use of various types of stem cells. Understanding the pathogenesis of SCI and the molecular mechanisms of stem cell action can improve the efficacy of SCT and lead to the development of new therapeutic approaches.

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A simple self-assembly nanomicelle based on brain tumor-targeting peptide-mediated siRNA delivery for glioma immunotherapy via intranasal administration

Lin Tang et al.

Summary: The blood-brain barrier plays a critical role in preventing drugs from entering the brain. Non-invasive intranasal drug delivery routes are becoming popular due to their ability to bypass the blood-brain barrier and reduce drug loss. However, the complex synthesis and limited mass production of most nose-to-brain delivery carriers hinder their clinical application.

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Article Engineering, Biomedical

Engineered extracellular vesicles for delivery of siRNA promoting targeted repair of traumatic spinal cord injury

Yuluo Rong et al.

Summary: In this study, a drug delivery system using engineered extracellular vesicles (EVs) carrying CAQK-modified peptide and loaded siRNA (C-EVs-siRNA) was designed for targeted therapy of spinal cord injury (SCI). The modified EVs effectively delivered siRNA to the SCI region and showed favorable therapeutic effects. The combination of targeted modified EVs and siRNA enhanced the anti-inflammatory and neuroreparative functions of EVs, promoting functional recovery in mice after SCI. This study highlights the potential of engineered EVs as a feasible and efficacious treatment for SCI and possibly other diseases.

BIOACTIVE MATERIALS (2023)

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Review Biochemistry & Molecular Biology

Small Drugs, Huge Impact: The Extraordinary Impact of Antisense Oligonucleotides in Research and Drug Development

Anais M. Quemener et al.

Summary: Antisense oligonucleotides (ASOs) are a versatile class of drugs that can precisely target RNA and alter nucleic acid function. In the context of the COVID-19 pandemic, ASOs may serve as a powerful tool to target the virus RNA and provide therapeutic strategies. However, no ASO has gained FDA approval yet.

MOLECULES (2022)

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Review Chemistry, Multidisciplinary

Overcoming barriers in non-viral gene delivery for neurological applications

Aaron Tasset et al.

Summary: Gene therapy for neurological disorders is being explored using non-viral vectors to optimize their characteristics and improve efficacy. Research has focused on improving blood-brain barrier transcytosis, enhancing perfusion in the brain, increasing cellular uptake and endosomal escape in neural cells, and promoting nuclear transport of genetic material. Multi-functional vectors have been successfully used in pre-clinical treatments for Parkinson's disease, brain cancers, and neuron replacement through cellular reprogramming.

NANOSCALE (2022)

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Review Cell Biology

Delving into the recent advancements of spinal cord injury treatment: a review of recent progress

Joseph A. Flack et al.

Summary: Spinal cord injury (SCI) research is complex, and reviewing current literature can benefit researchers. This review focuses on recent articles discussing potential modalities for SCI treatment and management. The modalities are categorized into four groups. PubMed was used to find relevant, peer-reviewed articles within the past two years. Preclinical studies have produced varied results, making replication in clinical studies challenging. Therefore, scientists should focus on understanding and applying previous research to improve preclinical studies and clinical trials.

NEURAL REGENERATION RESEARCH (2022)

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Article Cell Biology

Downregulation of EphB2 by RNA interference attenuates glial/fibrotic scar formation and promotes axon growth

Jian Wu et al.

Summary: This study found that suppression of EphB2 expression by RNAi can attenuate the formation of a glial/fibrotic scar and promote axon growth.

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Biomimetic Scaffolds for Spinal Cord Applications Exhibit Stiffness-Dependent Immunomodulatory and Neurotrophic Characteristics

Ian Woods et al.

Summary: The study found that Coll-IV/Fn mixture in scaffolds can promote axonal extension of neurons and induce morphological features of astrocytes. By using materials of different stiffness in the scaffold, astrocyte behavior can be regulated, and the production of anti-inflammatory cytokines can be stimulated.

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Article Cell Biology

CXCL4 drives fibrosis by promoting several key cellular and molecular processes

Alsya J. Affandi et al.

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CELL REPORTS (2022)

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Article Cell Biology

Microglia-Derived Exosomal microRNA-151-3p Enhances Functional Healing After Spinal Cord Injury by Attenuating Neuronal Apoptosis via Regulating the p53/p21/CDK1 Signaling Pathway

Chengjun Li et al.

Summary: In this study, the therapeutic effects of microglia-derived exosomes on neuronal apoptosis, axonal regrowth, and functional recovery after spinal cord injury (SCI) were explored using a contusive SCI mouse model and in vitro experiments. The findings showed that microglia-derived exosomes could promote neurological functional recovery by suppressing neuronal apoptosis and promoting axonal regrowth both in vivo and in vitro. MicroRNA-151-3p was found to be abundant in microglia-derived exosomes and necessary for mediating the neuroprotective effects of SCI treatments.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Review Biotechnology & Applied Microbiology

The Effect of miRNA-Modified Exosomes in Animal Models of Spinal Cord Injury: A meta-Analysis

Mengdie Hu et al.

Summary: MiRNA-modified exosomes have great potential in the treatment of spinal cord injury, and their efficacy is superior to that of exosomes alone. In addition, the SCI model, administration time, and dose have an impact on the treatment effect.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Review Biochemistry & Molecular Biology

Are Cell-Based Therapies Safe and Effective in the Treatment of Neurodegenerative Diseases? A Systematic Review with Meta-Analysis

Jasper Van den Bos et al.

Summary: In the field of regenerative medicine, significant progress has been made in the past two decades. Cell-based therapies in neurodegenerative diseases have shown to be safe and feasible, leading to promising clinical improvements. However, the high heterogeneity of research results calls for cautious interpretation.

BIOMOLECULES (2022)

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Article Biochemistry & Molecular Biology

Synthesis and Characterization of Fatty Acid Grafted Chitosan Polymeric Micelles for Improved Gene Delivery of VGF to the Brain through Intranasal Route

Richard Nii Lante Lamptey et al.

Summary: Multifunctional fatty acid grafted polymeric micelles have shown promise as an effective method for drug and gene delivery to the brain. Intranasal administration has been identified as an alternative approach to bypass the blood-brain barrier. In this research, polymeric micelles were prepared and characterized for the delivery of pVGF to the brain. The results showed that the modified chitosan polymer with mannose, Tat peptide, and oleic acid led to significantly higher expression of pVGF in primary astrocytes and neurons compared to intravenous administration. Intranasal administration also resulted in significantly higher pVGF expression compared to intravenous administration. These findings suggest that multifunctional polymeric micelles, especially those tagged with mannose and Tat ligands, are effective platforms for delivering pVGF to the brain.

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Review Chemistry, Multidisciplinary

Current state of the art in peptide-based gene delivery

Roja Hadianamrei et al.

Summary: Gene therapy involves correcting specific pathological conditions by introducing exogenous genetic materials into cells. However, efficient delivery of these materials is hindered by various barriers, necessitating the use of gene vectors. Peptides have emerged as promising biomaterials for gene delivery due to their desirable properties. This review provides an overview of recent advances in peptide-based gene delivery systems and focuses on systems composed solely of peptides.

JOURNAL OF CONTROLLED RELEASE (2022)

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Review Clinical Neurology

Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials

Carl M. Zipser et al.

Summary: Spinal cord injury is a debilitating condition that leads to impaired mobility, pain, and autonomic dysfunction. Cell-based and stem-cell-based therapies have shown promise in promoting functional recovery, but clinical trials have not yet provided reproducible evidence of their efficacy. However, recent trials have demonstrated the feasibility and long-term safety of cell transplantation into the injured spinal cord.

LANCET NEUROLOGY (2022)

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Spinal Cord Injury: A Systematic Review and Network Meta-Analysis of Therapeutic Strategies Based on 15 Types of Stem Cells in Animal Models

Zhizhong Shang et al.

Summary: This study aims to explore the optimal therapeutic strategies of stem cells for spinal cord injury (SCI) through animal studies, provide guidance for clinical practice, and offer references for future research and clinical studies. The results show that various types of stem cells can significantly improve locomotor function in animals with SCI, with adipose-derived mesenchymal stem cells having the greatest therapeutic potential. A higher dose of stem cell transplantation, transplantation in the subacute phase, and intralesional transplantation are considered optimal strategies.

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Intermittent lipid nanoparticle mRNA administration prevents cortical dysmyelination associated with arginase deficiency

Suhail Khoja et al.

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Testing preexisting antibodies prior to AAV gene transfer therapy: rationale, lessons and future considerations

Jerry R. Mendell et al.

Summary: This article discusses the importance of preexisting adaptive immunity to viral vectors in gene transfer therapy. It describes two different assays used to detect preexisting antibodies and strategies to overcome preexisting adaptive immunity.

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Microglia Polarization: A Novel Target of Exosome for Stroke Treatment

Teng Wan et al.

Summary: Exosomes are important vehicles for intercellular signaling and play a significant role in stroke regulation. There is a close link between microglia polarization and exosomes, where exosome inclusions such as microRNAs play a crucial role in regulating microglia polarization.

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How gene therapy is emerging from its ‘dark age’

Gemma Conroy

NATURE (2022)

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Review Cell Biology

The PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities

Xuegang He et al.

Summary: Traumatic spinal cord injury (TSCI) causes neurological dysfunction and significantly affects the quality of life in patients. The PI3K/AKT signaling pathway is a potential therapeutic target for the inhibition of secondary TSCI. This review summarizes the role of the PI3K/AKT pathway in TSCI and discusses current and potential future treatment methods based on this pathway.

CELL PROLIFERATION (2022)

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Review Neurosciences

Application and prospects of somatic cell reprogramming technology for spinal cord injury treatment

Riyun Yang et al.

Summary: Spinal cord injury is a challenging condition to treat, and current therapies cannot achieve complete recovery. Somatic cell reprogramming offers a promising approach by converting fibroblasts and other cells into neurons or oligodendrocytes for spinal cord repair.

FRONTIERS IN CELLULAR NEUROSCIENCE (2022)

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Review Neurosciences

The use of viral vectors to promote repair after spinal cord injury

Ashraful Islam et al.

Summary: Spinal cord injury is a devastating event that can permanently disrupt multiple functions, and delivering genetic material using viral vectors has the potential to promote axon regeneration and overcome obstacles. However, various factors should be considered when using viral vector for gene therapy. Gene therapy shows promise in preclinical models for treating spinal cord injury.

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A Localized Materials-Based Strategy to Non-Virally Deliver Chondroitinase ABC mRNA Improves Hindlimb Function in a Rat Spinal Cord Injury Model

Andrew S. Khalil et al.

Summary: Spinal cord injuries often have devastating consequences and limited therapeutic options. This study utilizes mineral-coated microparticles as efficient non-viral gene delivery vehicles to produce exogenous ChABC in spinal cord injuries, reducing CSPG deposition and improving motor function recovery.

ADVANCED HEALTHCARE MATERIALS (2022)

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A functionalized collagen-I scaffold delivers microRNA 21-loaded exosomes for spinal cord injury repair

Xingzhi Liu et al.

Summary: This study aims to develop genetically engineered miR21-loaded exosomes that can be stably tethered to a collagen-I scaffold, promoting the sustained release of miR21 and benefiting spinal cord injury repair.

ACTA BIOMATERIALIA (2022)

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Article Biotechnology & Applied Microbiology

Central Nervous System Gene Therapy: Present Developments and Emerging Trends Accelerating Industry-Academia Pathways

Margareta Rybarikova et al.

Summary: The recent success of the first central nervous system gene therapies has revitalized gene therapy research and increased clinical trials for neurologic diseases caused by genetic mutations. Advances in technology have expanded the scope of treatment applications and bridged the gap between major global health issues and gene therapy development.

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Development of PLGA Nanoparticles with a Glycosylated Myelin Oligodendrocyte Glycoprotein Epitope (MOG35-55) against Experimental Autoimmune Encephalomyelitis (EAE)

Iro Triantafyllakou et al.

Summary: This study developed polymeric nanoparticles loaded with myelin peptide analogues to inhibit the development and progression of multiple sclerosis. The results showed that this therapeutic approach effectively reduced clinical scores and CNS inflammation, suggesting it as a promising alternative for treating multiple sclerosis by inducing tolerance against the disease.

MOLECULAR PHARMACEUTICS (2022)

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Research on the function of the Cend1 regulatory mechanism on p75NTR signaling in spinal cord injury

Chen Chen et al.

Summary: Utilizing NSC repair mechanisms, minimizing neuron loss, and recovering damaged spinal cord functions are key challenges in spinal cord injury research. The interplay between Cend1 and p75NTR in regulating NSC differentiation and inhibiting neuronal apoptosis shows promise for innovative treatment strategies.

NEUROPEPTIDES (2022)

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Article Multidisciplinary Sciences

MiR-31 improves spinal cord injury in mice by promoting the migration of bone marrow mesenchymal stem cells

Yujuan Zhang et al.

Summary: This study found that miR-31 can promote the migration of bone marrow mesenchymal stem cells and has a reparative and improvement effect on damaged tissues in spinal cord injury.

PLOS ONE (2022)

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Article Engineering, Biomedical

Inflammatory Microenvironment-Responsive Nanomaterials Promote Spinal Cord Injury Repair by Targeting IRF5

Dezun Ma et al.

Summary: This study utilized polyethylenimine-conjugated, diselenide-bridged mesoporous silica nanoparticles to deliver siRNA to silence IRF5, effectively regulating the M1-to-M2 macrophage conversion. The functional nanomaterial showed promising results in suppressing excessive inflammation and promoting neuroprotection and locomotor restoration in spinal cord injury.

ADVANCED HEALTHCARE MATERIALS (2022)

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Review Pharmacology & Pharmacy

Exosomes as CNS Drug Delivery Tools and Their Applications

Ke Sun et al.

Summary: Central nervous system diseases pose a threat to global health, but developing drugs targeting the CNS is challenging due to the unique characteristics of the brain and spinal cord. Exosomes, as CNS drug delivery tools, stand out for their low immunogenicity, ability to cross the blood-brain barrier, and flexibility in drug encapsulation. Research over the past decade has shown the potential of exosomes in CNS drug delivery, and there are still challenges and prospects to be addressed.

PHARMACEUTICS (2022)

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Review Biotechnology & Applied Microbiology

The roles and applications of neural stem cells in spinal cord injury repair

Wen Guo et al.

Summary: This article introduces the potential of neural stem cells (NSCs) in repairing spinal cord injuries. NSCs, as multipotent stem cells, can differentiate into neurons and neuroglial lineages, making them an ideal choice for regenerating injured spinal cords. The article also discusses the sources and therapeutic potential of NSCs and introduces some relevant pre-clinical studies and clinical trials.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Review Cell & Tissue Engineering

Biomaterials delivery strategies to repair spinal cord injury by modulating macrophage phenotypes

Yuanliang Xia et al.

Summary: Spinal cord injury (SCI) causes significant harm to patients' physical, mental, and financial health. Inflammation is an important factor affecting SCI recovery, and the modulation of macrophage phenotypes appears to be a meaningful therapeutic target. Biomaterials, with their targeting and bio-compatibility properties, hold potential in modulating macrophage phenotypes for SCI recovery.

JOURNAL OF TISSUE ENGINEERING (2022)

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Review Engineering, Biomedical

Nonviral delivery systems for antisense oligonucleotide therapeutics

Si Huang et al.

Summary: In this article, a review of current nonviral delivery strategies for antisense oligonucleotides (ASOs) is provided, including modifications, action mechanisms, and multi-carrier methods. The irreplaceable role of nonviral vectors in the progressive development of ASOs delivery is emphasized.

BIOMATERIALS RESEARCH (2022)

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Article Cell & Tissue Engineering

Gene-Modified Stem Cells for Spinal Cord Injury: a Promising Better Alternative Therapy

Yirui Feng et al.

Summary: Stem cell therapy holds great promise for treating spinal cord injury by reversing neurodegeneration and promoting tissue regeneration. However, the clinical efficacy of current stem cell-based approaches is disappointing. This review summarizes the progress and potential of genetically modified stem cells for spinal cord injury treatment, focusing on genome editing tools and functional molecules involved in repair. It aims to provide a deeper understanding of genetically modified stem cell therapy and more applicable clinical strategies for spinal cord injury repair.

STEM CELL REVIEWS AND REPORTS (2022)

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Letter Biochemistry & Molecular Biology

Mutations of MSH5 in nonobstructive azoospermia (NOA) and rescued via in vivo gene editing

Min Chen et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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SDF-1α gene-activated collagen scaffold drives functional differentiation of human Schwann cells for wound healing applications

Ashang L. Laiva et al.

Summary: This study demonstrates that a SDF-1 alpha gene-activated scaffold can enhance proangiogenic responses in human SCs, potentially improving wound healing outcomes.

BIOTECHNOLOGY AND BIOENGINEERING (2021)

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Article Medicine, Research & Experimental

Design and Validation of Liposomal ApoE2 Gene Delivery System to Evade Blood-Brain Barrier for Effective Treatment of Alzheimer's Disease

Sanjay Arora et al.

Summary: This study demonstrated efficient brain-targeted delivery of ApoE2 gene therapy using surface-modified liposomes, with significantly higher ApoE2 expression in neurons and potential for effective AD treatment.

MOLECULAR PHARMACEUTICS (2021)

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Article Cell Biology

Human umbilical cord mesenchymal stem cells-derived extracellular vesicles facilitate the repair of spinal cord injury via the miR-29b-3p/PTEN/Akt/mTOR axis

Xiao Xiao et al.

Summary: HucMSCs-EVs demonstrated significant improvement in motor function and reduced pathology in SCI rats. These extracellular vesicles alleviated spinal cord neuronal injury. miR-29b-3p targeted PTEN, enhancing the repair effect on spinal cord injury.

CELL DEATH DISCOVERY (2021)

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Article Neurosciences

CCR2 downregulation attenuates spinal cord injury by suppressing inflammatory monocytes

Qingpu Zhang et al.

Summary: The use of siCCR2-loaded nanoparticles successfully downregulated CCR2, reduced the number of blood-derived macrophages/monocytes, and decreased pro-inflammatory cytokine production in spinal cord injury mice, thus promoting axon regeneration and locomotor function recovery.

SYNAPSE (2021)

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Article Engineering, Biomedical

Functionalization of Electrospun Polycaprolactone Scaffolds with Matrix-Binding Osteocyte-Derived Extracellular Vesicles Promotes Osteoblastic Differentiation and Mineralization

Mechiel Nieuwoudt et al.

Summary: Functionalized synthetic scaffolds can enhance bone regeneration properties by promoting osteogenic differentiation and matrix mineralization through the attachment of osteocyte-derived EVs. This matrix-based adhesion of EVs provides a mechanism for signal transmission in polyester scaffolds, demonstrating the potential of osteocyte-derived EVs to enhance bone tissue regeneration rate.

ANNALS OF BIOMEDICAL ENGINEERING (2021)

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Gene Therapy for Drug-Resistant Glioblastoma via Lipid-Polymer Hybrid Nanoparticles Combined with Focused Ultrasound

Qiang Yang et al.

Summary: In this study, LPHNs-cRGD were developed for targeted delivery of the CRISPR/Cas9 system, combined with FUS-MBs to open the BBB. The delivery system showed potential as an efficient targeted gene delivery option for treating glioblastoma.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Review Critical Care Medicine

Blood-Spinal Cord Barrier in Spinal Cord Injury: A Review

Lin-Yu Jin et al.

Summary: The blood-spinal cord barrier is a crucial barrier that prevents toxins, blood cells, and pathogens from entering the spinal cord, and its disruption plays a key role in the progression of spinal cord injury pathology. Repairing this disruption could alleviate the damage caused by SCI.

JOURNAL OF NEUROTRAUMA (2021)

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SDF-1α gene-activated collagen scaffold enhances provasculogenic response in a coculture of human endothelial cells with human adipose-derived stromal cells

Ashang L. Laiva et al.

Summary: The study demonstrates that a collagen scaffold containing SDF-1 alpha GAS enhances the communication between endothelial cells and stem cells, accelerates tissue regeneration by upregulating provascular genes, and produces a bioactive vascularized construct.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2021)

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Bioactive scaffolds with enhanced supramolecular motion promote recovery from spinal cord injury

Z. Alvarez et al.

Summary: Researchers have successfully utilized peptide amphiphile supramolecular polymers containing two distinct signals to achieve cell signaling and tissue regeneration in a mouse model of severe spinal cord injury. By mutating the peptide sequence of the monomers, they intensified the motions of molecules within scaffold fibrils, resulting in notable effects such as vascular growth, axonal regeneration, and functional recovery. The study suggests that optimizing cell signaling through ensembles of molecules could be achieved by tuning their internal motions.

SCIENCE (2021)

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Review Neurosciences

Extracellular Vesicles as an Emerging Frontier in Spinal Cord Injury Pathobiology and Therapy

Dipankar Dutta et al.

Summary: Extracellular vesicles (EVs) are membrane-delimited particles secreted by nearly all cell types, playing crucial roles in mediating physiological functions and pathophysiological processes in the central nervous system. Research has shown that EVs are important in neurotrauma such as spinal cord injury (SCI) and may serve as potential targets for therapy.

TRENDS IN NEUROSCIENCES (2021)

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Article Neurosciences

Bone marrow mesenchymal stem cell-derived exosomal microRNA-125a promotes M2 macrophage polarization in spinal cord injury by downregulating IRF5

Qing Chang et al.

Summary: B-Exo promotes recovery of locomotor function and M2-phenotype polarization, inhibits neuronal apoptosis and degeneration, as well as the inflammatory response in rats with SCI. IRF5 expression is reduced after B-Exo treatment, and it promotes macrophage polarization towards M1 phenotype and secretion of inflammatory factors. There is a binding relationship between miR-125a and IRF5, with the knockdown of miR-125a in B-Exo leading to increased IRF5 expression and attenuation of the neuroprotective effect against SCI.

BRAIN RESEARCH BULLETIN (2021)

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Article Biochemistry & Molecular Biology

RGS5-TGFβ-Smad2/3 axis switches pro- to anti-apoptotic signaling in tumor-residing pericytes, assisting tumor growth

Shayani Dasgupta et al.

Summary: This study reveals that TGF beta can limit the pro-apoptotic effect of RGS5 on tumor-associated pericytes in the tumor microenvironment, promoting their survival and expansion. The interaction between RGS5 and TGF beta regulates signaling pathways, allowing pericytes to survive in the tumor environment.

CELL DEATH AND DIFFERENTIATION (2021)

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Article Cell & Tissue Engineering

First-in-human clinical trial of transplantation of iPSC-derived NS/PCs in subacute complete spinal cord injury: Study protocol

Keiko Sugai et al.

Summary: Our group has conducted extensive studies on the use of human induced pluripotent cell-derived neural stem/progenitor cell grafts in models of spinal cord injury. We are preparing to initiate a first-in-human clinical study in subacute SCI patients. The study aims to assess safety and preliminary evidence of impact on neurological function and quality-of-life outcomes.

REGENERATIVE THERAPY (2021)

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Article Engineering, Biomedical

Delivery of pOXR1 through an injectable liposomal nanoparticle enhances spinal cord injury regeneration by alleviating oxidative stress

Jing Zhang et al.

Summary: The study evaluated the function of OXR1 in SCI and developed a new carrier for delivering OXR1, showing that the carrier can effectively enhance OXR1 expression and improve transfection efficiency. The results indicate that Nps-pOXR1-Lip has potential therapeutic effects in SCI treatment.

BIOACTIVE MATERIALS (2021)

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Review Surgery

Management of Acute Traumatic Spinal Cord Injury: A Review of the Literature

Timothy Y. Wang et al.

Summary: Traumatic spinal cord injury is a debilitating disease that presents significant functional and economic burdens. Prognosis depends on the extent of injury and severity of dysfunction, with rapid treatment crucial to prevent further damage. Managing TSCI patients involves various factors, from initial assessment to long-term care for optimal recovery.

FRONTIERS IN SURGERY (2021)

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Article Cell & Tissue Engineering

Exosomes derived from miR-26a-modified MSCs promote axonal regeneration via the PTEN/AKT/mTOR pathway following spinal cord injury

Yuyong Chen et al.

Summary: Exosomes derived from miR-26a-modified MSC can promote axonal regeneration, improve neurogenesis, and attenuate glial scarring through the PTEN/AKT/mTOR signaling cascades in spinal cord injury.

STEM CELL RESEARCH & THERAPY (2021)

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Article Clinical Neurology

Effects of the Tight Junction Protein CLDN6 on Cell Migration and Invasion in High-Grade Meningioma

Anqiang Yang et al.

Summary: CLDN6 expression levels impact meningioma invasiveness; higher expression in normal meningeal tissue; potential diagnostic and therapeutic target.

WORLD NEUROSURGERY (2021)

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Comparative Effectiveness of Intracerebroventricular, Intrathecal, and Intranasal Routes of AAV9 Vector Administration for Genetic Therapy of Neurologic Disease in Murine Mucopolysaccharidosis Type I

Lalitha R. Belur et al.

Summary: The study examined the effectiveness of AAV-mediated IDUA gene delivery to the brain through different routes of administration, finding that IT and IN routes were effective in preventing neurocognitive deficiencies in a mouse model of MPS I.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)

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Review Pharmacology & Pharmacy

Non-viral Vectors in Gene Therapy: Recent Development, Challenges, and Prospects

Hui Zu et al.

Summary: Although non-viral vectors in gene therapy have low cytotoxicity and immunogenicity, they still face challenges in gene transfer efficiency, specificity, gene expression duration, and safety. Overcoming these obstacles is necessary to enhance the effectiveness of non-viral vectors in gene therapy.

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Assessment of the Oral Delivery of a Myelin Basic Protein Gene Promoter with Antiapoptotic bcl-xL (pMBP-bcl-xL) DNA by Cyclic Peptide Nanotubes with Two Aspect Ratios and Its Biodistribution in the Brain and Spinal Cord

Jiahorng Liaw et al.

Summary: This study assessed the feasibility of cyclo-(D-Trp-Tyr) peptide nanotubes with different aspect ratios as carriers for oral gene delivery to treat spinal cord injury. Results showed that under in vitro conditions, peptide nanotubes with a smaller aspect ratio had a higher DNA release rate and permeation in the duodenum.

MOLECULAR PHARMACEUTICS (2021)

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Article Biochemistry & Molecular Biology

Long noncoding RNA ZFAS1 aggravates spinal cord injury by binding with miR-1953 and regulating the PTEN/PI3K/AKT pathway

Yunxiang Chen et al.

Summary: The study demonstrated that ZFAS1 promotes SCI progression by binding with miR-1953 and regulating the PTEN/PI3K/AKT pathway, which may offer a novel insight for SCI treatment.

NEUROCHEMISTRY INTERNATIONAL (2021)

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Article Cell & Tissue Engineering

SiRNA in MSC-derived exosomes silences CTGF gene for locomotor recovery in spinal cord injury rats

Wei Huang et al.

Summary: This study utilized exosomes as carriers for delivering synthesized siRNA, effectively inhibiting CTGF gene expression and promoting locomotor recovery in rats with spinal cord injury (SCI). The combination of gene therapy thoroughness and exosomes' excellent drug-loading characteristics offers new insights into precise treatment of SCI.

STEM CELL RESEARCH & THERAPY (2021)

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Article Chemistry, Multidisciplinary

A 3D Fiber-Hydrogel Based Non-Viral Gene Delivery Platform Reveals that microRNAs Promote Axon Regeneration and Enhance Functional Recovery Following Spinal Cord Injury

Na Zhang et al.

Summary: A novel therapeutic approach for spinal cord injuries involving scaffold-mediated Axon miR treatment with methylprednisolone significantly enhances axon regeneration and functional recovery, while reducing inflammation gene expression.

ADVANCED SCIENCE (2021)

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Review Cell Biology

Mesenchymal Stem Cells in Treatment of Spinal Cord Injury and Amyotrophic Lateral Sclerosis

Eva Sykova et al.

Summary: MSCs, as candidates in regenerative medicine, have shown significant therapeutic potential in animal experiments and clinical studies due to their immunomodulatory, paracrine, and neural stimulation effects.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Cell Biology

Emerging Exosomes and Exosomal MiRNAs in Spinal Cord Injury

Jia Feng et al.

Summary: Exosomes, as intracellular mediators, have been implicated in the pathophysiological processes of various diseases, including spinal cord injury. They are considered to potentially play a significant role in the treatment of SCI.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Cell & Tissue Engineering

Extracellular vesicles derived from mesenchymal stem cells containing microRNA-381 protect against spinal cord injury in a rat model via the BRD4/WNT5A axis

X. Jia et al.

Summary: The microRNA miR-381 derived from MSC-EVs can promote the recovery of SCI through the BRD4/WNT5A axis, providing a new perspective on SCI treatment.

BONE & JOINT RESEARCH (2021)

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Article Materials Science, Biomaterials

Gene activated scaffolds incorporating star-shaped polypeptide-pDNA nanomedicines accelerate bone tissue regeneration in vivo

David P. Walsh et al.

Summary: Novel star-polypeptide biomaterials carrying two therapeutic genes incorporated into a cell-free scaffold have shown promising results in accelerating bone tissue regeneration, offering a potential solution to clinical challenges such as large bone defects.

BIOMATERIALS SCIENCE (2021)

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Article Materials Science, Biomaterials

In vitro vascularization of tissue engineered constructs by non-viral delivery of pro-angiogenic genes

Helena R. Moreira et al.

Summary: Delivery of genes encoding angiogenic growth factors to cells in a scaffold microenvironment can lead to controlled release of angiogenic proteins promoting vascularization and providing structural support for new matrix deposition.

BIOMATERIALS SCIENCE (2021)

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Article Cell & Tissue Engineering

Direct neuronal differentiation of neural stem cells for spinal cord injury repair

Weiwei Xue et al.

Summary: Transplantation of neural stem cells shows promise for restoring communication in spinal cord injury, but the inhibitory microenvironment often leads to glial differentiation rather than neuronal differentiation. Functional biomaterials can mitigate the adverse effects of the SCI microenvironment and promote neuronal differentiation of NSCs.

STEM CELLS (2021)

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Article Cell & Tissue Engineering

Lithium modulates miR-1906 levels of mesenchymal stem cell-derived extracellular vesicles contributing to poststroke neuroprotection by toll-like receptor 4 regulation

Matteo Haupt et al.

Summary: Preconditioning of MSCs with lithium enhances the therapeutic potential of EVs, specifically Li-EVs, which show increased resistance against hypoxic injury and improved neurological recovery in poststroke models. Additionally, Li-EVs modify the contents of miRNAs to inhibit TLR4 signaling pathway and reduce poststroke cerebral inflammation, providing acute neuroprotection and enhanced neurological recovery.

STEM CELLS TRANSLATIONAL MEDICINE (2021)

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Article Neurosciences

Intranasal Delivery oflincRNA-Cox2siRNA Loaded Extracellular Vesicles Decreases Lipopolysaccharide-Induced Microglial Proliferation in Mice

Ke Liao et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2020)

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Review Biochemistry & Molecular Biology

The Struggle to Make CNS Axons Regenerate: Why Has It Been so Difficult?

James W. Fawcett

NEUROCHEMICAL RESEARCH (2020)

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Article Cell Biology

Fibroblast growth factor-2/platelet-derived growth factor enhances atherosclerotic plaque stability

Yang Mao et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Medicine, General & Internal

CELLTOP Clinical Trial: First Report From a Phase 1 Trial of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells in the Treatment of Paralysis Due to Traumatic Spinal Cord Injury

Mohamad Bydon et al.

MAYO CLINIC PROCEEDINGS (2020)

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Article Cell & Tissue Engineering

Epidermal growth factor receptor-extracellular-regulated kinase blockade upregulates TRIM32 signaling cascade and promotes neurogenesis after spinal cord injury

Weiwei Xue et al.

STEM CELLS (2020)

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Review Pharmacology & Pharmacy

Liposomes: Novel Drug Delivery Approach for Targeting Parkinson's Disease

Bhumika Kumar et al.

CURRENT PHARMACEUTICAL DESIGN (2020)

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Review Medicine, Research & Experimental

Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem

Jarred M. Griffin et al.

EMBO MOLECULAR MEDICINE (2020)

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Article Biochemistry & Molecular Biology

The transcription factor Foxd3 induces spinal cord ischemia-reperfusion injury by potentiating microRNA-214-dependent inhibition of Kcnk2

Ran Li et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

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Article Biochemistry & Molecular Biology

The inhibition of miR-17-5p promotes cortical neuron neurite growth via STAT3/GAP-43 pathway

Liang Zhang et al.

MOLECULAR BIOLOGY REPORTS (2020)

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Review Biotechnology & Applied Microbiology

Immune Responses to Viral Gene Therapy Vectors

Jamie L. Shirley et al.

MOLECULAR THERAPY (2020)

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Review Chemistry, Applied

Recent advances in natural polymer-based drug delivery systems

Xianqin Tong et al.

REACTIVE & FUNCTIONAL POLYMERS (2020)

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Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

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Article Clinical Neurology

Intravenous delivery of microRNA-133b along with Argonaute-2 enhances spinal cord recovery following cervical contusion in mice

Camelia A. Danilov et al.

SPINE JOURNAL (2020)

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Review Pharmacology & Pharmacy

Opportunities and Challenges in the Delivery of mRNA-Based Vaccines

Abishek Wadhwa et al.

PHARMACEUTICS (2020)

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Development of anin situinjectable hydrogel containing hyaluronic acid for neural regeneration

Linh T. B. Nguyen et al.

BIOMEDICAL MATERIALS (2020)

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Article Biochemistry & Molecular Biology

Exosomes derived from miR-544-modified mesenchymal stem cells promote recovery after spinal cord injury

Chenggnag Li et al.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2020)

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Article Nanoscience & Nanotechnology

Arginine-Modified Polymers Facilitate Poly (Lactide-Co-Glycolide)-Based Nanoparticle Gene Delivery to Primary Human Astrocytes

Jessica Proulx et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Review Endocrinology & Metabolism

Multifaceted roles of pericytes in central nervous system homeostasis and disease

Zhitong Zheng et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2020)

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Article Engineering, Biomedical

Activation of the SOX-5, SOX-6, and SOX-9 Trio of Transcription Factors Using a Gene-Activated Scaffold Stimulates Mesenchymal Stromal Cell Chondrogenesis and Inhibits Endochondral Ossification

Rosanne M. Raftery et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Article Neurosciences

MiR-615 Regulates NSC Differentiation In Vitro and Contributes to Spinal Cord Injury Repair by Targeting LINGO-1

Hongfu Wu et al.

MOLECULAR NEUROBIOLOGY (2020)

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Article Medicine, General & Internal

Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson's Disease

Jeffrey S. Schweitzer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Neurosciences

Comparison of high-dose intracisterna magna and lumbar puncture intrathecal delivery of AAV9 in mice to treat neuropathies

Rachel M. Bailey et al.

BRAIN RESEARCH (2020)

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Article Medicine, Research & Experimental

Translational Feasibility of Lumbar Puncture for Intrathecal AAV Administration

Christian Hinderer et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2020)

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Review Cell Biology

Macrophage Modification Strategies for Efficient Cell Therapy

Anastasiya S. Poltavets et al.

CELLS (2020)

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Article Medicine, Research & Experimental

miR-27a promotion resulting from silencing of HDAC3 facilitates the recovery of spinal cord injury by inhibiting PAK6 expression in rats

Qingzhong Zhou et al.

LIFE SCIENCES (2020)

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Article Biotechnology & Applied Microbiology

Combination of In Situ Lcn2 pRNA-RNAi Nanotherapeutics and iNSC Transplantation Ameliorates Experimental SCI in Mice

Alice Braga et al.

MOLECULAR THERAPY (2020)

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Article Cell & Tissue Engineering

Human bone marrow stem/stromal cell osteogenesis is regulated via mechanically activated osteocyte-derived extracellular vesicles

Kian F. Eichholz et al.

STEM CELLS TRANSLATIONAL MEDICINE (2020)

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Review Neurosciences

Beyond barrier functions: Roles of pericytes in homeostasis and regulation of neuroinflammation

Anindita Bhattacharya et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2020)

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Article Materials Science, Biomaterials

Collagen/GAG scaffolds activated by RALA-siMMP-9 complexes with potential for improved diabetic foot ulcer healing

Le-Ping Yan et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Biochemistry & Molecular Biology

Lipid Nanoparticles Vectorized with NFL-TBS.40-63 Peptide Target Oligodendrocytes and Promote Neurotrophin-3 Effects After Demyelination In Vitro

Catherine Fressinaud et al.

NEUROCHEMICAL RESEARCH (2020)

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Article Multidisciplinary Sciences

Gold nanocarriers for transport of oligonucleotides across brain endothelial cells

Nayab Fatima et al.

PLOS ONE (2020)

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Article Multidisciplinary Sciences

Microenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery

Kun Xi et al.

NATURE COMMUNICATIONS (2020)

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Review Biochemistry & Molecular Biology

Treatment of spinal cord injury with mesenchymal stem cells

Ling Ling Liau et al.

CELL AND BIOSCIENCE (2020)

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Article Medicine, Research & Experimental

MicroRNA-135a-5p Promotes the Functional Recovery of Spinal Cord Injury by Targeting SP1 and ROCK

Nanxiang Wang et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

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Review Chemistry, Multidisciplinary

Strategies and materials of SMARTnon-viral vectors: Overcoming the barriers for brain gene therapy

Yan Li et al.

NANO TODAY (2020)

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Article Pharmacology & Pharmacy

Layered Double Hydroxide as a Potent Non-viral Vector for Nucleic Acid Delivery Using Gene-Activated Scaffolds for Tissue Regeneration Applications

Lara S. Costard et al.

PHARMACEUTICS (2020)

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Article Neurosciences

Forkhead Box M1 promotes the growth and tube formation of human malignant meningioma cells via the aryl hydrocarbon receptor signaling pathway

Qiang Wu et al.

FOLIA NEUROPATHOLOGICA (2020)

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Article Cell Biology

Effects of miR-219/miR-338 on microglia and astrocyte behaviors and astrocyte-oligodendrocyte precursor cell interactions

Lan Huong Nguyen et al.

NEURAL REGENERATION RESEARCH (2020)

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Article Clinical Neurology

The Damaged Spinal Cord Is a Suitable Target for Stem Cell Transplantation

Armin Curt et al.

NEUROREHABILITATION AND NEURAL REPAIR (2020)

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Article Engineering, Biomedical

Microglia-targeting nanotherapeutics for neurodegenerative diseases

Nanxia Zhao et al.

APL BIOENGINEERING (2020)

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Article Cell & Tissue Engineering

NeuroRegen Scaffolds Combined with Autologous Bone Marrow Mononuclear Cells for the Repair of Acute Complete Spinal Cord Injury: A 3-Year Clinical Study

Wugui Chen et al.

CELL TRANSPLANTATION (2020)

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Review Neurosciences

Localised non-viral delivery of nucleic acids for nerve regeneration in injured nervous systems

Na Zhang et al.

EXPERIMENTAL NEUROLOGY (2019)

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Article Critical Care Medicine

Clinical Outcomes from a Multi-Center Study of Human Neural Stem Cell Transplantation in Chronic Cervical Spinal Cord Injury

Allan D. Levi et al.

JOURNAL OF NEUROTRAUMA (2019)

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Article Nanoscience & Nanotechnology

Intranasal delivery of hGDNF plasmid DNA nanoparticles results in long-term and widespread transfection of perivascular cells in rat brain

Amirah E-E. Aly et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2019)

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Review Clinical Neurology

Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms

Arsalan Alizadeh et al.

FRONTIERS IN NEUROLOGY (2019)

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Review Engineering, Biomedical

Polymer scaffolds facilitate spinal cord injury repair

Qingzheng Zhang et al.

ACTA BIOMATERIALIA (2019)

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Review Clinical Neurology

The origin, fate, and contribution of macrophages to spinal cord injury pathology

Lindsay M. Milich et al.

ACTA NEUROPATHOLOGICA (2019)

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Review Orthopedics

Scaffold-Based Delivery of Nucleic Acid Therapeutics for Enhanced Bone and Cartilage Repair

Domhnall C. Kelly et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2019)

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Review Cell & Tissue Engineering

Employing Endogenous NSCs to Promote Recovery of Spinal Cord Injury

Sumei Liu et al.

STEM CELLS INTERNATIONAL (2019)

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Article Chemistry, Multidisciplinary

Scalable Fabrication of Porous Microchannel Nerve Guidance Scaffolds with Complex Geometries

Dena Shahriari et al.

ADVANCED MATERIALS (2019)

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Article Hematology

Role of TPBG (Trophoblast Glycoprotein) Antigen in Human Pericyte Migratory and Angiogenic Activity

Helen L. Spencer et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2019)

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Article Medicine, Research & Experimental

Mesenchymal stem cell derived EVs mediate neuroprotection after spinal cord injury in rats via the microRNA-21-5p/FasL gene axis

Xin Zhou et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Review Clinical Neurology

Modern Medical Management of Spinal Cord Injury

Michael Karsy et al.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2019)

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Article Chemistry, Multidisciplinary

Controlling the dose-dependent, synergistic and temporal effects of NGF and GDNF by encapsulation in PLGA microparticles for use in nerve guidance conduits for the repair of large peripheral nerve defects

William A. Lackington et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Review Biochemistry & Molecular Biology

Spinal cord repair: advances in biology and technology

Gregoire Courtine et al.

NATURE MEDICINE (2019)

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Article Neurosciences

Chondroitinase improves anatomical and functional outcomes after primate spinal cord injury

Ephron S. Rosenzweig et al.

NATURE NEUROSCIENCE (2019)

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Article Virology

Recombinant Adeno-Associated Virus Gene Therapy in Light of Luxturna (and Zolgensma and Glybera): Where Are We, and How Did We Get Here?

Allison M. Keeler et al.

ANNUAL REVIEW OF VIROLOGY, VOL 6, 2019 (2019)

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Article Chemistry, Multidisciplinary

Intranasal Delivery of Mesenchymal Stem Cell Derived Exosomes Loaded with Phosphatase and Tensin Homolog siRNA Repairs Complete Spinal Cord Injury

Shaowei Guo et al.

ACS NANO (2019)

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Review Neurosciences

Challenges of gene delivery to the central nervous system and the growing use of biomaterial vectors

Devan L. Puhl et al.

BRAIN RESEARCH BULLETIN (2019)

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Article Pharmacology & Pharmacy

Tumor targeting peptides: novel therapeutic strategies in glioblastoma

Drazen Raucher

CURRENT OPINION IN PHARMACOLOGY (2019)

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Article Medicine, Research & Experimental

Prospects of siRNA cocktails as tools for modifying multiple gene targets in the injured spinal cord

Felicia Mary Michael et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2019)

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Article Biochemistry & Molecular Biology

MiR-21 derived from the exosomes of MSCs regulates the death and differentiation of neurons in patients with spinal cord injury

Jian Kang et al.

GENE THERAPY (2019)

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Article Medicine, Research & Experimental

Enhancement of Motor Function Recovery after Spinal Cord Injury in Mice by Delivery of Brain-Derived Neurotrophic Factor mRNA

Samuel T. Crowley et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

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Review Neurosciences

Recent advances in the therapeutic uses of chondroitinase ABC

E. Muir et al.

EXPERIMENTAL NEUROLOGY (2019)

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Review Biochemistry & Molecular Biology

Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers

Mariana Castro Dias et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Multidisciplinary Sciences

Cell adhesion signals regulate the nuclear receptor activity

Kotaro Sugimoto et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Multidisciplinary Sciences

A single combination gene therapy treats multiple age-related diseases

Noah Davidsohn et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Review Multidisciplinary Sciences

Moving beyond the glial scar for spinal cord repair

Elizabeth J. Bradbury et al.

NATURE COMMUNICATIONS (2019)

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Review Pharmacology & Pharmacy

Recent advances in nanotherapeutic strategies for spinal cord injury repair

Young Hye Song et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

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Article Biochemistry & Molecular Biology

miR-21 deficiency contributes to the impaired protective effects of obese rat mesenchymal stem cell-derived exosomes against spinal cord injury

Wenchen Ji et al.

BIOCHIMIE (2019)

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Article Cell Biology

miR-21 and miR-19b delivered by hMSC-derived EVs regulate the apoptosis and differentiation of neurons in patients with spinal cord injury

Guanghui Xu et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Biotechnology & Applied Microbiology

Scaffold-Mediated Sustained, Non-viral Delivery of miR-219/miR-338 Promotes CNS Remyelination

Ulla Milbreta et al.

MOLECULAR THERAPY (2019)

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Article Biochemistry & Molecular Biology

Biomimetic 3D-printed scaffolds for spinal cord injury repair

Jacob Koffler et al.

NATURE MEDICINE (2019)

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Article Medicine, General & Internal

Carbon monoxide releasing molecule-3 alleviates neuron death after spinal cord injury via inflammasome regulation

Gang Zheng et al.

EBIOMEDICINE (2019)

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Review Medicine, Research & Experimental

Supramolecular Assemblies of Peptides or Nucleopeptides for Gene Delivery

Huaimin Wang et al.

THERANOSTICS (2019)

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Article Biology

Estimating transfection efficiency in differentiated and undifferentiated neural cells

Abeer A. Alabdullah et al.

BMC RESEARCH NOTES (2019)

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Article Biology

Exosomes secreted from miRNA-29b-modified mesenchymal stem cells repaired spinal cord injury in rats

Tao Yu et al.

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2019)

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Article Nanoscience & Nanotechnology

Antitumor effect of a new nano-vector with miRNA-135a on malignant glioma

Chaofeng Liang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Article Clinical Neurology

Pericytes Make Spinal Cord Breathless after Injury

Viviani M. Almeida et al.

NEUROSCIENTIST (2018)

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Article Engineering, Biomedical

Scaffold-Based microRNA Therapies in Regenerative Medicine and Cancer

Caroline M. Curtin et al.

ADVANCED HEALTHCARE MATERIALS (2018)

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Article Engineering, Biomedical

RGD/TAT-functionalized chitosan-graft-PEI-PEG gene nanovector for sustained delivery of NT-3 for potential application in neural regeneration

Dongni Wu et al.

ACTA BIOMATERIALIA (2018)

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Article Engineering, Biomedical

In vitro efficacy of a gene-activated nerve guidance conduit incorporating non-viral PEI-pDNA nanoparticles carrying genes encoding for NGF, GDNF and c-Jun

William A. Lackington et al.

ACTA BIOMATERIALIA (2018)

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Article Biochemistry & Molecular Biology

Noninvasive, targeted gene therapy for acute spinal cord injury using LIFU-mediated BDNF-loaded cationic nanobubble destruction

Zhaojun Song et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Review Medicine, Research & Experimental

Treatment targets for M2 microglia polarization in ischemic stroke

Ji Wang et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Medicine, Research & Experimental

Cathepsins: Proteases that are vital for survival but can also be fatal

Seema Patel et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Biotechnology & Applied Microbiology

A simple protocol for transfecting human mesenchymal stem cells

Talita Giacomet de Carvalho et al.

BIOTECHNOLOGY LETTERS (2018)

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Article Clinical Neurology

Immune-evasive gene switch enables regulated delivery of chondroitinase after spinal cord injury

Emily R. Burnside et al.

BRAIN (2018)

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Article Biochemistry & Molecular Biology

Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury

David Oliveira Dias et al.

CELL (2018)

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Article Cell & Tissue Engineering

Single-Factor SOX2 Mediates Direct Neural Reprogramming of Human Mesenchymal Stem Cells via Transfection of In Vitro Transcribed mRNA

Bo-Eun Kim et al.

CELL TRANSPLANTATION (2018)

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Article Biotechnology & Applied Microbiology

Severe Toxicity in Nonhuman Primates and Piglets Following High-Dose Intravenous Administration of an Adeno-Associated Virus Vector Expressing Human SMN

Christian Hinderer et al.

HUMAN GENE THERAPY (2018)

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Article Pharmacology & Pharmacy

Pro-angiogenic impact of SDF-1α gene-activated collagen-based scaffolds in stem cell driven angiogenesis

Ashang Luwang Laiva et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

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Article Clinical Neurology

A multicenter, randomized, double-blind, dose-finding study of condoliase in patients with lumbar disc herniation

Yukihiro Matsuyama et al.

JOURNAL OF NEUROSURGERY-SPINE (2018)

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Article Materials Science, Biomaterials

hucMSC derived exosomes promote functional recovery in spinal cord injury mice via attenuating inflammation

Guodong Sun et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

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Review Biochemistry & Molecular Biology

Fibrotic scarring following lesions to the central nervous system

David Oliveira Dias et al.

MATRIX BIOLOGY (2018)

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Article Biotechnology & Applied Microbiology

Local Immunomodulation with Anti-inflammatory Cytokine-Encoding Lentivirus Enhances Functional Recovery after Spinal Cord Injury

Jonghyuck Park et al.

MOLECULAR THERAPY (2018)

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Review Neurosciences

Astrocyte reactivity and astrogliosis after spinal cord injury

Seiji Okada et al.

NEUROSCIENCE RESEARCH (2018)

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Article Biochemistry & Molecular Biology

Cell-penetrating peptides for siRNA delivery to glioblastomas

Artita Srimanee et al.

PEPTIDES (2018)

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Article Biochemistry & Molecular Biology

The nociceptin receptor inhibits axonal regeneration and recovery from spinal cord injury

Yuichi Sekine et al.

SCIENCE SIGNALING (2018)

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Review Neurosciences

Extracellular Vesicles: Multimodal Envoys in Neural Maintenance and Repair

Mea M. Holm et al.

TRENDS IN NEUROSCIENCES (2018)

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Article Biochemistry & Molecular Biology

The nociceptin receptor inhibits axonal regeneration and recovery from spinal cord injury

Yuichi Sekine et al.

SCIENCE SIGNALING (2018)

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Article Medicine, Research & Experimental

RNA Nanotherapeutics for the Amelioration of Astroglial Reactivity

Jayden A. Smith et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2018)

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Review Medicine, Research & Experimental

Emerging Issues in AAV-Mediated In Vivo Gene Therapy

Pasqualina Colella et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2018)

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Review Medicine, Research & Experimental

Cell penetrating peptides: A concise review with emphasis on biomedical applications

Hossein Derakhshankhah et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Chemistry, Multidisciplinary

Dual functionalized liposome-mediated gene delivery across triple co-culture blood brain barrier model and specific in vivo neuronal transfection

Bruna dos Santos Rodrigues et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Multidisciplinary Sciences

Required growth facilitators propel axon regeneration across complete spinal cord injury

Mark A. Anderson et al.

NATURE (2018)

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Article Endocrinology & Metabolism

Up-regulation of TNF Receptor-associated Factor 7 after spinal cord injury in rats may have implication for neuronal apoptosis

Dawei Xu et al.

NEUROPEPTIDES (2018)

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Correction Multidisciplinary Sciences

Three-dimensional aligned nanofibers-hydrogel scaffold for controlled non-viral drug/gene delivery to direct axon regeneration in spinal cord injury treatment (vol 7, 42212, 2017)

Lan Huong Nguyen et al.

SCIENTIFIC REPORTS (2018)

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Article Materials Science, Biomaterials

Scaffold mediated gene knockdown for neuronal differentiation of human neural progenitor cells

Wai Hon Chooi et al.

BIOMATERIALS SCIENCE (2018)

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Intrinsic Determinants of Axon Regeneration

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DEVELOPMENTAL NEUROBIOLOGY (2018)

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Review Biotechnology & Applied Microbiology

Recent advancements in the use of exosomes as drug delivery systems

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JOURNAL OF NANOBIOTECHNOLOGY (2018)

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Article Genetics & Heredity

Intranasal administration of exosomes derived from mesenchymal stem cells ameliorates autistic-like behaviors of BTBR mice

Nisim Perets et al.

MOLECULAR AUTISM (2018)

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Review Cell & Tissue Engineering

Hydrogel-based scaffolds to support intrathecal stem cell transplantation as a gateway to the spinal cord: clinical needs, biomaterials, and imaging technologies

J. Miguel Oliveira et al.

NPJ REGENERATIVE MEDICINE (2018)

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Article Biochemistry & Molecular Biology

The Expression of IGFBP6 after Spinal Cord Injury: Implications for Neuronal Apoptosis

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NEUROCHEMICAL RESEARCH (2017)

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Article Pharmacology & Pharmacy

Synthetic nanocarriers for the delivery of polynucleotides to the eye

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EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

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Review Immunology

Reactive Astrocytes: Production, Function, and Therapeutic Potential

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IMMUNITY (2017)

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Nerve growth factor delivery by ultrasound-mediated nanobubble destruction as a treatment for acute spinal cord injury in rats

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INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Article Pharmacology & Pharmacy

Non-viral vectors based on magnetoplexes, lipoplexes and polyplexes for VEGF gene delivery into central nervous system cells

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INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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Article Critical Care Medicine

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Attenuates Apoptosis, Inflammation, and Promotes Angiogenesis after Spinal Cord Injury in Rats

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Article Oncology

The role of the miR-99b-5p/mTOR signaling pathway in neuroregeneration in mice following spinal cord injury

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MOLECULAR MEDICINE REPORTS (2017)

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Article Multidisciplinary Sciences

Neurotoxic reactive astrocytes are induced by activated microglia

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NATURE (2017)

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Review Neurosciences

Cell transplantation therapy for spinal cord injury

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NATURE NEUROSCIENCE (2017)

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Nischarin-siRNA delivered by polyethyleniminealginate nanoparticles accelerates motor function recovery after spinal cord injury

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NEURAL REGENERATION RESEARCH (2017)

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Review Cell Biology

RhoA as a target to promote neuronal survival and axon regeneration

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A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions

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Human Neural Stem Cell Transplantation in Chronic Cervical Spinal Cord Injury: Functional Outcomes at 12 Months in a Phase II Clinical Trial

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NEUROSURGERY (2017)

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Article Engineering, Biomedical

A Physicochemically Optimized and Neuroconductive Biphasic Nerve Guidance Conduit for Peripheral Nerve Repair

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Olfactory Derived Stem Cells Delivered in a Biphasic Conduit Promote Peripheral Nerve Repair In Vivo

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STEM CELLS TRANSLATIONAL MEDICINE (2017)

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Selective rab11 transport and the intrinsic regenerative ability of CNS axons

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Article Biotechnology & Applied Microbiology

Targeted siRNA delivery reduces nitric oxide mediated cell death after spinal cord injury

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JOURNAL OF NANOBIOTECHNOLOGY (2017)

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Article Instruments & Instrumentation

Development of antibody-modified chitosan nanoparticles for the targeted delivery of si A across the blood-brain barrier as a strategy for inhibiting HIV replication in astrocytes

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DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2017)

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Article Cell & Tissue Engineering

Strategies for neurotrophin-3 and chondroitinase ABC release from freeze-cast chitosan-alginate nerve-guidance scaffolds

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JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2017)

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Article Neurosciences

MiR-17 targets PTEN and facilitates glial scar formation after spinal cord injuries via the PI3K/Akt/mTOR pathway

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BRAIN RESEARCH BULLETIN (2017)

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Article Cell & Tissue Engineering

Clinical Study of NeuroRegen Scaffold Combined With Human Mesenchymal Stem Cells for the Repair of Chronic Complete Spinal Cord Injury

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CELL TRANSPLANTATION (2017)

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Article Neurosciences

RNAi-mediated ephrin-B2 silencing attenuates astroglial-fibrotic scar formation and improves spinal cord axon growth

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CNS NEUROSCIENCE & THERAPEUTICS (2017)

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Article Engineering, Biomedical

Physical chitosan microhydrogels as scaffolds for spinal cord injury restoration and axon regeneration

Jamila Chedly et al.

BIOMATERIALS (2017)

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Article Engineering, Biomedical

RhoA knockdown by cationic amphiphilic copolymer/siRhoA polyplexes enhances axonal regeneration in rat spinal cord injury model

So-Jung Gwak et al.

BIOMATERIALS (2017)

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Tailoring minimalist self-assembling peptides for localized viral vector gene delivery

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NANO RESEARCH (2016)

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Neuron-Targeted Nanoparticle for siRNA Delivery to Traumatic Brain Injuries

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ACS NANO (2016)

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Article Engineering, Biomedical

Cationic, amphiphilic copolymer micelles as nucleic acid carriers for enhanced transfection in rat spinal cord

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ACTA BIOMATERIALIA (2016)

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Article Chemistry, Multidisciplinary

Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy

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Article Chemistry, Multidisciplinary

Delivering Nucleic-Acid Based Nanomedicines on Biomaterial Scaffolds for Orthopedic Tissue Repair: Challenges, Progress and Future Perspectives

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ADVANCED MATERIALS (2016)

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Article Engineering, Biomedical

Treatment of spinal cord injury by an advanced cell transplantation technology using brain-derived neurotrophic factor-transfected mesenchymal stem cell spheroids

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BIOMATERIALS (2016)

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Article Biochemistry & Molecular Biology

Characterization of a novel adeno-associated viral vector with preferential oligodendrocyte tropism

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GENE THERAPY (2016)

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Article Cell Biology

Nanoparticle-Delivered IRF5 siRNA Facilitates M1 to M2 Transition, Reduces Demyelination and Neurofilament Loss, and Promotes Functional Recovery After Spinal Cord Injury in Mice

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INFLAMMATION (2016)

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Article Chemistry, Multidisciplinary

Mesenchymal stem cell and derived exosome as small RNA carrier and Immunomodulator to improve islet transplantation

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Article Chemistry, Multidisciplinary

Part II: Functional delivery of a neurotherapeutic gene to neural stem cells using minicircle DNA and nanoparticles: Translational advantages for regenerative neurology

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Article Chemistry, Multidisciplinary

Non-invasive, neuron-specific gene therapy by focused ultrasound-induced blood-brain barrier opening in Parkinson's disease mouse model

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Article Oncology

Aberrant DNA methylation of alternative promoter of DLC1 isoform 1 in meningiomas

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Article Neurosciences

Astrocytic GAP43 Induced by the TLR4/NF-κB/STAT3 Axis Attenuates Astrogliosis-Mediated Microglial Activation and Neurotoxicity

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Review Neurosciences

Quantum Dots and Potential Therapy for Krabbe's Disease

Glyn Dawson

JOURNAL OF NEUROSCIENCE RESEARCH (2016)

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Article Clinical Neurology

Hyaluronic acid scaffold has a neuroprotective effect in hemisection spinal cord injury

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JOURNAL OF NEUROSURGERY-SPINE (2016)

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Article Public, Environmental & Occupational Health

Risks Associated With Lentiviral Vector Exposures and Prevention Strategies

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JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE (2016)

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Article Biochemistry & Molecular Biology

The role and regulatory mechanism of IL-1 on the methylation of the NF2 gene in benign meningiomas and leptomeninges

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MOLECULAR CARCINOGENESIS (2016)

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Article Nanoscience & Nanotechnology

Chitosan polyplex mediated delivery of miRNA-124 reduces activation of microglial cells in vitro and in rat models of spinal cord injury

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NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2016)

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Article Biochemistry & Molecular Biology

PCBP2 Modulates Neural Apoptosis and Astrocyte Proliferation After Spinal Cord Injury

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NEUROCHEMICAL RESEARCH (2016)

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Review Neurosciences

Intrinsic Control of Axon Regeneration

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NEURON (2016)

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Article Neurosciences

NON-VIRAL XYLOSYLTRANSFERASE-1 siRNA DELIVERY AS AN EFFECTIVE ALTERNATIVE TO CHONDROITINASE IN AN IN VITRO MODEL OF REACTIVE ASTROCYTES

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NEUROSCIENCE (2016)

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Article Clinical Neurology

A Phase III Clinical Trial Showing Limited Efficacy of Autologous Mesenchymal Stem Cell Therapy for Spinal Cord Injury

Sun Kyu Oh et al.

NEUROSURGERY (2016)

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Article Cell & Tissue Engineering

Gene Delivery of TGF-β3 and BMP2 in an MSC-Laden Alginate Hydrogel for Articular Cartilage and Endochondral Bone Tissue Engineering

Tomas Gonzalez-Fernandez et al.

TISSUE ENGINEERING PART A (2016)

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Review Cell Biology

Exosome-mediated small RNA delivery for gene therapy

Yu Zhou et al.

WILEY INTERDISCIPLINARY REVIEWS-RNA (2016)

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Article Materials Science, Biomaterials

Nanoparticle-mediated conversion of primary human astrocytes into neurons and oligodendrocytes

Xiaowei Li et al.

BIOMATERIALS SCIENCE (2016)

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Review Pharmacology & Pharmacy

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

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ACTA PHARMACEUTICA SINICA B (2016)

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Review Neurosciences

Exosomes as a Nanodelivery System: a Key to the Future of Neuromedicine?

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MOLECULAR NEUROBIOLOGY (2016)

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Article Multidisciplinary Sciences

Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease

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SCIENTIFIC REPORTS (2016)

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Article Engineering, Biomedical

Enhanced BBB permeability of osmotically active poly(mannitol-co-PEI) modified with rabies virus glycoprotein via selective stimulation of caveolar endocytosis for RNAi therapeutics in Alzheimer's disease

Tae-Eun Park et al.

BIOMATERIALS (2015)

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Article Engineering, Biomedical

Myelin repair in vivo is increased by targeting oligodendrocyte precursor cells with nanoparticles encapsulating leukaemia inhibitory factor (LIF)

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BIOMATERIALS (2015)

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Article Engineering, Biomedical

Topographical effects on fiber-mediated microRNA delivery to control oligodendroglial precursor cells development

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BIOMATERIALS (2015)

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Macrophage activation and its role in repair and pathology after spinal cord injury

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BRAIN RESEARCH (2015)

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Article Neurosciences

Neurotrophic factors for spinal cord repair: Which, where, how and when to apply, and for what period of time?

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BRAIN RESEARCH (2015)

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Article Biochemistry & Molecular Biology

Gene delivery to the spinal cord using MRI-guided focused ultrasound

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GENE THERAPY (2015)

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Review Neurosciences

Endogenous neural stem cell responses to stroke and spinal cord injury

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GLIA (2015)

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Article Engineering, Biomedical

Multifunctional nanoparticles for gene delivery and spinal cord injury

So-Jung Gwak et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2015)

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Article Chemistry, Multidisciplinary

Intrathecal injection of a therapeutic gene-containing polyplex to treat spinal cord injury

Kentaro Hayakawa et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Article Chemistry, Multidisciplinary

Nanofiber-mediated microRNA delivery to enhance differentiation and maturation of oligodendroglial precursor cells

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JOURNAL OF CONTROLLED RELEASE (2015)

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Article Chemistry, Multidisciplinary

Exosomes as drug delivery vehicles for Parkinson's disease therapy

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JOURNAL OF CONTROLLED RELEASE (2015)

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Article Chemistry, Multidisciplinary

Drug delivery, cell-based therapies, and tissue engineering approaches for spinal cord injury

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JOURNAL OF CONTROLLED RELEASE (2015)

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Article Biochemistry & Molecular Biology

Mussel-Inspired Modification of Nanofibers for REST siRNA Delivery: Understanding the Effects of Gene-Silencing and Substrate Topography on Human Mesenchymal Stem Cell Neuronal Commitment

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MACROMOLECULAR BIOSCIENCE (2015)

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Review Biochemistry & Molecular Biology

Cell-Type Specific Penetrating Peptides: Therapeutic Promises and Challenges

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MOLECULES (2015)

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Injury-Induced Decline of Intrinsic Regenerative Ability Revealed by Quantitative Proteomics

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NEURON (2015)

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Article Neurosciences

Meninges harbor cells expressing neural precursor markers during development and adulthood

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FRONTIERS IN CELLULAR NEUROSCIENCE (2015)

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Article Multidisciplinary Sciences

Modulation of Macrophage Functional Polarity towards Anti-Inflammatory Phenotype with Plasmid DNA Delivery in CD44 Targeting Hyaluronic Acid Nanoparticles

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SCIENTIFIC REPORTS (2015)

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Review Medicine, Research & Experimental

siRNA Versus miRNA as Therapeutics for Gene Silencing

Jenny K. W. Lam et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2015)

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Article Orthopedics

Acute complications of spinal cord injuries

Ellen Merete Hagen

WORLD JOURNAL OF ORTHOPEDICS (2015)

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Article Genetics & Heredity

Adenovirus Vectors for Gene Therapy, Vaccination and Cancer Gene Therapy

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CURRENT GENE THERAPY (2014)

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Review Genetics & Heredity

Towards an understanding of semaphorin signalling in the spinal cord

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GENE (2014)

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Article Biochemistry & Molecular Biology

Intranasal administration of plasmid DNA nanoparticles yields successful transfection and expression of a reporter protein in rat brain

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GENE THERAPY (2014)

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Article Immunology

Glutathione PEGylated liposomal methylprednisolone (2B3-201) attenuates CNS inflammation and degeneration in murine myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis

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JOURNAL OF NEUROIMMUNOLOGY (2014)

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Article Neurosciences

Differences in the Phagocytic Response of Microglia and Peripheral Macrophages after Spinal Cord Injury and Its Effects on Cell Death

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JOURNAL OF NEUROSCIENCE (2014)

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Article Cardiac & Cardiovascular Systems

In Vivo Silencing of the Transcription Factor IRF5 Reprograms the Macrophage Phenotype and Improves Infarct Healing

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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2014)

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Article Oncology

Silencing ephrinB3 improves functional recovery following spinal cord injury

Yang Qu et al.

MOLECULAR MEDICINE REPORTS (2014)

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Article Neurosciences

Insulin/IGF1 Signaling Inhibits Age-Dependent Axon Regeneration

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NEURON (2014)

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Article Neurosciences

Selective inhibition of STAT1 reduces spinal cord injury in mice

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NEUROSCIENCE LETTERS (2014)

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Astrocyte activation is suppressed in both normal and injured brain by FGF signaling

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Article Cell & Tissue Engineering

Mesenchymal Stem Cells Deliver Exogenous miRNAs to Neural Cells and Induce Their Differentiation and Glutamate Transporter Expression

Hae Kyung Lee et al.

STEM CELLS AND DEVELOPMENT (2014)

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Review Pharmacology & Pharmacy

Gene therapy strategies for the treatment of spinal cord injury

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THERAPEUTIC DELIVERY (2014)

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Article Biochemistry & Molecular Biology

GDNF Gene Delivery via a 2-(Dimethylamino)ethyl Methacrylate Based Cyclized Knot Polymer for Neuronal Cell Applications

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ACS CHEMICAL NEUROSCIENCE (2013)

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Acellular vascular grafts generated from collagen and elastin analogs

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ACTA BIOMATERIALIA (2013)

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Article Engineering, Biomedical

Delivery of siRNA to the brain using a combination of nose-to-brain delivery and cell-penetrating peptide-modified nano-micelles

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BIOMATERIALS (2013)

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Article Engineering, Biomedical

Nanofibrous scaffold-mediated REST knockdown to enhance neuronal differentiation of stem cells

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BIOMATERIALS (2013)

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Article Hematology

mRNA-engineered mesenchymal stem cells for targeted delivery of interleukin-10 to sites of inflammation

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BLOOD (2013)

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Article Medicine, Research & Experimental

Usage of Plasmid Vector Carrying vegf and fgf2 Genes after Spinal Cord Injury in Rats

G. F. Shaymardanova et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2013)

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Article Biochemistry & Molecular Biology

Improved axonal regeneration of transected spinal cord mediated by multichannel collagen conduits functionalized with neurotrophin-3 gene

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GENE THERAPY (2013)

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Article Chemistry, Multidisciplinary

Mesoporous silica-supported lipid bilayers (protocells) for DNA cargo delivery to the spinal cord

Ellen C. Dengler et al.

JOURNAL OF CONTROLLED RELEASE (2013)

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Article Neurosciences

Perivascular Fibroblasts Form the Fibrotic Scar after Contusive Spinal Cord Injury

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JOURNAL OF NEUROSCIENCE (2013)

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Article Neurosciences

Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation

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NATURE NEUROSCIENCE (2013)

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Article Biochemistry & Molecular Biology

Role of Telomerase Reverse Transcriptase in Glial Scar Formation After Spinal Cord Injury in Rats

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NEUROCHEMICAL RESEARCH (2013)

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Article Neurosciences

IMPROVED AXONAL REGENERATION AFTER SPINAL CORD INJURY IN MICE WITH CONDITIONAL DELETION OF EPHRIN B2 UNDER THE GFAP PROMOTER

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NEUROSCIENCE (2013)

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Article Multidisciplinary Sciences

Nanotopography-mediated Reverse Uptake for siRNA Delivery into Neural Stem Cells to Enhance Neuronal Differentiation

Aniruddh Solanki et al.

SCIENTIFIC REPORTS (2013)

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Article Chemistry, Multidisciplinary

Innovative Collagen Nano-Hydroxyapatite Scaffolds Offer a Highly Efficient Non-Viral Gene Delivery Platform for Stem Cell-Mediated Bone Formation

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ADVANCED MATERIALS (2012)

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Article Biotechnology & Applied Microbiology

Silencing of miR20a Is Crucial for Ngn1-Mediated Neuroprotection in Injured Spinal Cord

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HUMAN GENE THERAPY (2012)

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Article Chemistry, Multidisciplinary

Lipid peptide nanocomplexes for gene delivery and magnetic resonance imaging in the brain

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JOURNAL OF CONTROLLED RELEASE (2012)

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Review Chemistry, Multidisciplinary

Therapeutic plasmid DNA versus siRNA delivery: Common and different tasks for synthetic carriers

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JOURNAL OF CONTROLLED RELEASE (2012)

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Article Multidisciplinary Sciences

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

Ursula Fuenfschilling et al.

NATURE (2012)

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Letter Biotechnology & Applied Microbiology

Glybera and the future of gene therapy in the European Union

Norman Miller

NATURE REVIEWS DRUG DISCOVERY (2012)

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Review Neurosciences

Assembly of a new growth cone after axotomy: the precursor to axon regeneration

Frank Bradke et al.

NATURE REVIEWS NEUROSCIENCE (2012)

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Review Pharmacology & Pharmacy

Intranasal drug delivery: An efficient and non-invasive route for systemic administration Focus on opioids

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PHARMACOLOGY & THERAPEUTICS (2012)

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Article Clinical Neurology

Life expectancy after spinal cord injury: a 50-year study

J. W. Middleton et al.

SPINAL CORD (2012)

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Article Immunology

The formyl peptide receptor like-1 and scavenger receptor MARCO are involved in glial cell activation in bacterial meningitis

Benedikt J. Braun et al.

JOURNAL OF NEUROINFLAMMATION (2011)

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Article Clinical Neurology

Spatiotemporal CCR1, CCL3(MIP-1α), CXCR4, CXCL12(SDF-1α) expression patterns in a rat spinal cord injury model of posttraumatic neuropathic pain

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JOURNAL OF NEUROSURGERY-SPINE (2011)

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Article Biotechnology & Applied Microbiology

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

Xiaoying Zhuang et al.

MOLECULAR THERAPY (2011)

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Article Biotechnology & Applied Microbiology

Therapeutic siRNA silencing in inflammatory monocytes in mice

Florian Leuschner et al.

NATURE BIOTECHNOLOGY (2011)

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Article Biotechnology & Applied Microbiology

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Lydia Alvarez-Erviti et al.

NATURE BIOTECHNOLOGY (2011)

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Article Immunology

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

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NATURE IMMUNOLOGY (2011)

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Article Biochemistry & Molecular Biology

MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-alpha-PU.1 pathway

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NATURE MEDICINE (2011)

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Review Genetics & Heredity

Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges

Federico Mingozzi et al.

NATURE REVIEWS GENETICS (2011)

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Review Neurosciences

Repertoire of microglial and macrophage responses after spinal cord injury

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NATURE REVIEWS NEUROSCIENCE (2011)

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Article Biochemistry & Molecular Biology

Down-regulation of glutamine synthetase enhances migration of rat astrocytes after in vitro injury

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NEUROCHEMISTRY INTERNATIONAL (2011)

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Article Multidisciplinary Sciences

A Pericyte Origin of Spinal Cord Scar Tissue

Christian Goritz et al.

SCIENCE (2011)

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Article Cell & Tissue Engineering

Nestin- and Doublecortin-Positive Cells Reside in Adult Spinal Cord Meninges and Participate in Injury-Induced Parenchymal Reaction

Ilaria Decimo et al.

STEM CELLS (2011)

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Article Engineering, Biomedical

Patterned transgene expression in multiple-channel bridges after spinal cord injury

Laura De Laporte et al.

ACTA BIOMATERIALIA (2010)

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Article Chemistry, Multidisciplinary

Angiopoiesis and bone regeneration via co-expression of the hVEGF and hBMP genes from an adeno-associated viral vector in vitro and in vivo

Chen Zhang et al.

ACTA PHARMACOLOGICA SINICA (2010)

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Article Behavioral Sciences

Genetically engineered mesenchymal stem cells reduce behavioral deficits in the YAC 128 mouse model of Huntington's disease

Nicholas D. Dey et al.

BEHAVIOURAL BRAIN RESEARCH (2010)

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Article Oncology

Carbosilane Dendrimers to Transfect Human Astrocytes with Small Interfering RNA Targeting Human Immunodeficiency Virus

Jose Luis Jimenez et al.

BIODRUGS (2010)

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Review Biochemistry & Molecular Biology

Participation of galactosylceramide and sulfatide in glycosynapses between oligodendrocyte or myelin membranes

Joan M. Boggs et al.

FEBS LETTERS (2010)

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Article Biochemistry & Molecular Biology

Stem cells in the adult rat spinal cord: plasticity after injury and treadmill training exercise

Ariane Foret et al.

JOURNAL OF NEUROCHEMISTRY (2010)

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Article Neurosciences

PTEN deletion enhances the regenerative ability of adult corticospinal neurons

Kai Liu et al.

NATURE NEUROSCIENCE (2010)

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Article Chemistry, Multidisciplinary

Release of Plasmid DNA-Encoding IL-10 from PLGA Microparticles Facilitates Long-Term Reversal of Neuropathic Pain Following a Single Intrathecal Administration

Ryan Gene Soderquist et al.

PHARMACEUTICAL RESEARCH (2010)

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Article Engineering, Biomedical

Local gene delivery from ECM-coated poly(lactide-co-glycolide) multiple channel bridges after spinal cord injury

Laura De Laporte et al.

BIOMATERIALS (2009)

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Review Engineering, Biomedical

Nanoparticle-mediated local delivery of methylprednisolone after spinal cord injury

Young-tae Kim et al.

BIOMATERIALS (2009)

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Article Engineering, Biomedical

The use of folate-PEG-grafted-hybranched-PEI nonviral vector for the inhibition of glioma growth in the rat

Bing Liang et al.

BIOMATERIALS (2009)

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Article Cell & Tissue Engineering

Compacted DNA Nanoparticle Gene Transfer of GDNF to the Rat Striatum Enhances the Survival of Grafted Fetal Dopamine Neurons

David M. Yurek et al.

CELL TRANSPLANTATION (2009)

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Article Biochemistry & Molecular Biology

Gene delivery to human adult and embryonic cell-derived stem cells using biodegradable nanoparticulate polymeric vectors

F. Yang et al.

GENE THERAPY (2009)

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Article Neurosciences

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

Kristina A. Kigerl et al.

JOURNAL OF NEUROSCIENCE (2009)

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Article Biotechnology & Applied Microbiology

Intrathecal Injection of Naked Plasmid DNA Provides Long-term Expression of Secreted Proteins

Travis S. Hughes et al.

MOLECULAR THERAPY (2009)

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Article Biotechnology & Applied Microbiology

Plasmid Releasing Multiple Channel Bridges for Transgene Expression After Spinal Cord Injury

Laura De Laporte et al.

MOLECULAR THERAPY (2009)

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Editorial Material Biochemistry & Molecular Biology

Beware the immune system in spinal cord injury

Phillip Popovich et al.

NATURE MEDICINE (2009)

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Article Neurosciences

SOCS3 Deletion Promotes Optic Nerve Regeneration In Vivo

Patrice D. Smith et al.

NEURON (2009)

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Article Multidisciplinary Sciences

Generation of mouse-induced pluripotent stem cells by transient expression of a single nonviral polycistronic vector

Federico Gonzalez et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Article Medicine, General & Internal

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

Ravid Shechter et al.

PLOS MEDICINE (2009)

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Article Clinical Neurology

Remyelination protects axons from demyelination-associated axon degeneration

K. A. Irvine et al.

BRAIN (2008)

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Review Pharmacology & Pharmacy

Pericytes: Pluripotent cells of the blood brain barrier

Paula Dore-Duffy

CURRENT PHARMACEUTICAL DESIGN (2008)

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Article Neurosciences

STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury

Julia E. Herrmann et al.

JOURNAL OF NEUROSCIENCE (2008)

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Article Multidisciplinary Sciences

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

Kevin Kyungsuk Park et al.

SCIENCE (2008)

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Article Neurosciences

Disorganized microtubules underlie the formation of retraction bulbs and the failure of axonal regeneration

Ali Ertuerk et al.

JOURNAL OF NEUROSCIENCE (2007)

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Article Pathology

Pericyte Rho GTPase mediates both pericyte contractile phenotype and capillary endothelial growth state

Matthew E. Kutcher et al.

AMERICAN JOURNAL OF PATHOLOGY (2007)

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Article Multidisciplinary Sciences

AAV vector integration sites in mouse hepatocellular carcinoma

Anthony Donsante et al.

SCIENCE (2007)

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Article Multidisciplinary Sciences

Transvascular delivery of small interfering RNA to the central nervous system

Priti Kumar et al.

NATURE (2007)

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Review Polymer Science

Chemical modification of chitosan as a gene carrier in vitro and in vivo

Tae-Hee Kim et al.

PROGRESS IN POLYMER SCIENCE (2007)

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Article Biochemistry & Molecular Biology

Identification and characterization of scirr1, a novel gene up-regulated after spinal cord injury

Tao Liu et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2007)

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Review Pharmacology & Pharmacy

Matrices and scaffolds for DNA delivery in tissue engineering

Laura De Laporte et al.

ADVANCED DRUG DELIVERY REVIEWS (2007)

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Article Neurosciences

DNA vaccine against NgR promotes functional recovery after spinal cord injury in adult rats

Panpan Yu et al.

BRAIN RESEARCH (2007)

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Article Clinical Neurology

The spine service line - Optimizing patient-centered spine care

Brian Kwon et al.

SPINE (2007)

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Article Engineering, Biomedical

Self-assembled ternary complexes of plasmid DNA, low molecular weight polyethylenimine and targeting peptide for nonviral gene delivery into neurons

Jieming Zeng et al.

BIOMATERIALS (2007)

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Article Chemistry, Multidisciplinary

Spinal gene transfer using ultrasound and microbubbles

Masahiko Takahashi et al.

JOURNAL OF CONTROLLED RELEASE (2007)

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Article Clinical Neurology

Gene transfer of insulin-like growth factor-I providing neuroprotection after spinal cord injury in rats

Kuo-Sheng Hung et al.

JOURNAL OF NEUROSURGERY-SPINE (2007)

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Article Neurosciences

GDNF gene delivery via the p75NTR receptor rescues injured motor neurons

Shahram Barati et al.

EXPERIMENTAL NEUROLOGY (2006)

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Article Neurosciences

Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury

A. W. Barritt et al.

JOURNAL OF NEUROSCIENCE (2006)

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Review Pharmacology & Pharmacy

Natural polymers for gene delivery and tissue engineering

Jiyoung M. Dang et al.

ADVANCED DRUG DELIVERY REVIEWS (2006)

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Review Critical Care Medicine

Chemorepellent axon guidance molecules in spinal cord injury

SP Niclou et al.

JOURNAL OF NEUROTRAUMA (2006)

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Article Critical Care Medicine

Collagen matrix in spinal cord

N Klapka et al.

JOURNAL OF NEUROTRAUMA (2006)

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Article Neurosciences

Intrathecal polymer-based interleukin-10*gene delivery for neuropathic pain

Erin D. Milligan et al.

NEURON GLIA BIOLOGY (2006)

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Review Chemistry, Physical

Polymers for gene delivery across length scales

David Putnam

NATURE MATERIALS (2006)

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Article Cardiac & Cardiovascular Systems

Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vector

YL Tang et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2005)

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Article Biochemistry & Molecular Biology

Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase

BL Song et al.

MOLECULAR CELL (2005)

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Article Neurosciences

Targeted retrograde gene delivery into the injured cervical spinal cord using recombinant adenovirus vector

H Nakajima et al.

NEUROSCIENCE LETTERS (2005)

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Article Neurosciences

Demyelination and Schwann cell responses adjacent to injury epicenter cavities following chronic human spinal cord injury

JD Guest et al.

EXPERIMENTAL NEUROLOGY (2005)

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Article Clinical Neurology

Spinal cord injury induction of lesional expression of profibrotic and angiogenic connective tissue growth factor confined to reactive astrocytes, invading fibroblasts and endothelial cells

S Conrad et al.

JOURNAL OF NEUROSURGERY-SPINE (2005)

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Article Neurosciences

Functional repair after dorsal root rhizotomy using nerve conduits and neurotrophic molecules

XQ Tang et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2004)

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Article Biochemistry & Molecular Biology

Neuronal plasticity after spinal cord injury: identification of a gene cluster driving neurite outgrowth

S Di Giovanni et al.

FASEB JOURNAL (2004)

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Article Biochemistry & Molecular Biology

Immune responses to gene therapy vectors: influence on vector function and effector mechanisms

N Bessis et al.

GENE THERAPY (2004)

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Article Biochemistry & Molecular Biology

Repeated intrathecal administration of plasmid DNA complexed with polyethylene glycol-grafted polyethylenimine led to prolonged transgene expression in the spinal cord

L Shi et al.

GENE THERAPY (2003)

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Article Neurosciences

Meningeal cell-derived semaphorin 3A inhibits neurite outgrowth

SP Niclou et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2003)

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Article Critical Care Medicine

Cationic liposome-mediated GDNF gene transfer after spinal cord injury

KW Lu et al.

JOURNAL OF NEUROTRAUMA (2002)

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Article Neurosciences

Injury-induced class 3 semaphorin expression in the rat spinal cord

F De Winter et al.

EXPERIMENTAL NEUROLOGY (2002)

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Article Multidisciplinary Sciences

Chondroitinase ABC promotes functional recovery after spinal cord injury

EJ Bradbury et al.

NATURE (2002)

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Article Biochemistry & Molecular Biology

Substrate hydrolysis by matrix metalloproteinase-9

SJ Kridel et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Review Neurosciences

Neurotrophic factors, cellular bridges and gene therapy for spinal cord injury

LL Jones et al.

JOURNAL OF PHYSIOLOGY-LONDON (2001)

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Article Neurosciences

Partial functional recovery of paraplegic rat by adenovirus-mediated gene delivery of constitutively active MEK1

T Miura et al.

EXPERIMENTAL NEUROLOGY (2000)

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Article Biochemistry & Molecular Biology

Cell cycle dependence of gene transfer by lipoplex polyplex and recombinant adenovirus

S Brunner et al.

GENE THERAPY (2000)

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Article Multidisciplinary Sciences

Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1

MS Chen et al.

NATURE (2000)

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Article Multidisciplinary Sciences

Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein

T GrandPré et al.

NATURE (2000)

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Article Clinical Neurology

Single injections of a DNA plasmid that contains the human Bcl-2 gene prevent loss and atrophy of distinct neuronal populations after spinal cord injury in adult rats

S Masato et al.

NEUROREHABILITATION AND NEURAL REPAIR (2000)

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