期刊
NEW PHYTOLOGIST
卷 211, 期 3, 页码 1020-1034出版社
WILEY
DOI: 10.1111/nph.13967
关键词
autophagy; Cauliflower mosaic virus; effector protein; innate immunity; oxidative burst; RNA silencing; salicylic acid (SA); target-of-rapamycin
资金
- Swiss National Science Foundation [31003A_143882]
- Swiss Government Excellence Scholarship
- Swiss National Science Foundation (SNF) [31003A_143882] Funding Source: Swiss National Science Foundation (SNF)
Virus interactions with plant silencing and innate immunity pathways can potentially alter the susceptibility of virus-infected plants to secondary infections with nonviral pathogens. We found that Arabidopsis plants infected with Cauliflower mosaic virus (CaMV) or transgenic for CaMV silencing suppressor P6 exhibit increased susceptibility to Pseudomonas syringae pv. tomato (Pst) and allow robust growth of the Pst mutant hrcC-, which cannot deploy effectors to suppress innate immunity. The impaired antibacterial defense correlated with the suppressed oxidative burst, reduced accumulation of the defense hormone salicylic acid (SA) and diminished SA-dependent autophagy. The viral protein domain required for suppression of these plant defense responses is dispensable for silencing suppression but essential for binding and activation of the plant target-of-rapamycin (TOR) kinase which, in its active state, blocks cellular autophagy and promotes CaMV translation. Our findings imply that CaMV P6 is a versatile viral effector suppressing both silencing and innate immunity. P6-mediated suppression of oxidative burst and SA-dependent autophagy may predispose CaMV-infected plants to bacterial infection.
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