期刊
NEW JOURNAL OF CHEMISTRY
卷 40, 期 9, 页码 7504-7512出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6nj01170e
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资金
- UGC, New Delhi [F-20-1/2012(BSR)/20-2(15)/2012(BSR)]
Simple and efficient protocols have been developed for the synthesis of diversely functionalized dihydro-2-oxypyrroles and tetrahydropyridines. One-pot four-component reaction of dialkyl acetylenedicarboxylates, amines and formaldehyde in the presence of 2,6-pyridinedicarboxylic acid in methanol at room temperature provides dihydro-2-oxypyrroles. The combination of beta-ketoesters, aromatic aldehydes and amines yielded tetrahydropyridine derivatives under the same reaction conditions. The salient features of these methods are mild reaction conditions, reduced reaction time, moderate to high yields, applicability to a broad range of substrates and no tedious column chromatographic separation.
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